32 Result(s)

Article

Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology

The highest incidence of sepsis across all age groups occurs in neonates leading to substantial mortality and morbidity. Cardiovascular dysfunction frequently complicates neonatal sepsis including biventricula...

Sophie M. Duignan, Satyan Lakshminrusimha, Kathryn Armstrong… in Pediatric Research (2024)

Article

Nutrition of the preterm infant with persistent ductus arteriosus: existing evidence and practical implications

The persistence of a patent ductus arteriosus (PDA) is a common condition in preterm infants with a prevalence inversely proportional to gestational age. PDA is associated with mild-to-severe gastrointestinal ...

Chiara Lembo, Afif El-Khuffash, Christoph Fusch, Silvia Iacobelli… in Pediatric Research (2023)

Article

The impact of a PDA on tissue oxygenation and haemodynamics following a blood transfusion in preterm infants

To examine the impact of PRBC transfusion on pulmonary vascular resistance (PVR), systemic vascular resistance and myocardial function using echocardiography and cerebral and splanchnic tissue oxygenation usin...

Aisling Smith, Sean Armstrong, Eugene Dempsey, Afif EL-Khuffash in Pediatric Research (2023)

Article

The role of furosemide and fluid management for a hemodynamically significant patent ductus arteriosus in premature infants

A patent ductus arteriosus (PDA) in infants born premature can present significant management challenges for neonatal providers. Quantifying a hemodynamically significant PDA (hsPDA) represents the first hurdl...

Sarah Dudley, Shawn Sen, Alison Hanson, Afif El Khuffash… in Journal of Perinatology (2022)

Article

Reply to correspondence

Afif EL-Khuffash, Patrick McNamara in Journal of Perinatology (2022)

Article

Cerebral oxygen saturation and autoregulation during hypotension in extremely preterm infants

The impact of the permissive hypotension approach in clinically well infants on regional cerebral oxygen saturation (rScO₂) and autoregulatory capacity (CAR) remains unknown.

Liesbeth Thewissen, Gunnar Naulaers, Dries Hendrikx… in Pediatric Research (2021)

Article

A review of the role of extracellular vesicles in neonatal physiology and pathology

Extracellular vesicles (EVs) are cell-derived membrane-bound particles, extensively investigated across many fields to improve the understanding of pathophysiological processes, as biomarkers of disease and as...

Claire A. Murphy, Daniel P. O’Reilly, Elaine Neary, Afif EL-Khuffash… in Pediatric Research (2021)

Article

Patent ductus arteriosus shunt elimination results in a reduction in adverse outcomes: a post hoc analysis of the PDA RCT cohort

A post hoc appraisal of the PDA RCT to assess the relationship between early patent ductus arteriosus (PDA) shunt elimination and chronic lung disease or death (CLD/Death).

Neidín Bussmann, Aisling Smith, Colm R. Breatnach… in Journal of Perinatology (2021)

Article

The unintended consequences of acetaminophen use for ductal closure in premature infants

David Staunton, Afif EL-Khuffash in Pediatric Research (2020)

Article

Preventing disease in the 21st century: early breast milk exposure and later cardiovascular health in premature infants

Cardiovascular health of premature infants reaching early adulthood is an area of ongoing research. There is emerging evidence delineating the challenges faced by those individuals. Young adults born premature...

Afif EL-Khuffash, Amish Jain, Adam J. Lewandowski, Philip T. Levy in Pediatric Research (2020)

Article

Cardiac mechanics in infants with Down syndrome in the early neonatal period

The objective of this study is to test whether myocardial performance is impaired over the first week of age in infants with Down syndrome (DS) without congenital heart disease (CHD).

Colm R. Breatnach, Neidin Bussmann, Aisling Smith, Phil Levy… in Journal of Perinatology (2019)

Article

Future perspectives on the use of deformation analysis to identify the underlying pathophysiological basis for cardiovascular compromise in neonates

The assessment of the wellbeing of the cardiovascular status in premature infants has come to the forefront in recent years. There is an increasing realisation that myocardial performance, systemic blood flow ...

Neidin Bussmann, Afif EL-Khuffash in Pediatric Research (2019)

Article

Early diastolic dysfunction and respiratory morbidity in premature infants: an observational study

To test if diastolic dysfunction measured on day one of age is associated with the need for invasive ventilation in preterm infants.

Neidin Bussmann, Colm Breatnach, Philip T. Levy, Naomi McCallion… in Journal of Perinatology (2018)