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Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology
The highest incidence of sepsis across all age groups occurs in neonates leading to substantial mortality and morbidity. Cardiovascular dysfunction frequently complicates neonatal sepsis including biventricula...
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Nutrition of the preterm infant with persistent ductus arteriosus: existing evidence and practical implications
The persistence of a patent ductus arteriosus (PDA) is a common condition in preterm infants with a prevalence inversely proportional to gestational age. PDA is associated with mild-to-severe gastrointestinal ...
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Open AccessPatent ductus arteriosus, bronchopulmonary dysplasia and pulmonary hypertension—a complex conundrum with many phenotypes?
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The impact of a PDA on tissue oxygenation and haemodynamics following a blood transfusion in preterm infants
To examine the impact of PRBC transfusion on pulmonary vascular resistance (PVR), systemic vascular resistance and myocardial function using echocardiography and cerebral and splanchnic tissue oxygenation usin...
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The use of milrinone in neonates with persistent pulmonary hypertension of the newborn - a randomised controlled trial pilot study (MINT 1)
To assess the impact of milrinone administration on time spent on nitric oxide (iNO) in infants with acute pulmonary hypertension (aPH). We hypothesized that intravenous milrinone used in conjunction with iNO ...
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The role of furosemide and fluid management for a hemodynamically significant patent ductus arteriosus in premature infants
A patent ductus arteriosus (PDA) in infants born premature can present significant management challenges for neonatal providers. Quantifying a hemodynamically significant PDA (hsPDA) represents the first hurdl...
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Open AccessThe effect of patent ductus arteriosus treatment with paracetamol on pulmonary vascular resistance
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Open AccessInfants with Down syndrome and congenital heart disease have altered peri-operative immune responses
Infants with Down syndrome (DS) have an altered immune response. We aimed to characterise the inflammatory response in infants with DS and congenital heart disease (CHD) peri-operatively in comparison to infan...
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Open AccessBiochemical testing for inborn errors of metabolism: experience from a large tertiary neonatal centre
Inborn errors of metabolism are an individually rare but collectively significant cause of mortality and morbidity in the neonatal period. They are identified by either newborn screening programmes or clinicia...
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Open AccessSurvey highlighting the lack of consensus on diagnosis and treatment of patent ductus arteriosus in prematurity
To gain insight in the availability of guidelines, diagnostic criteria, and treatment strategies and whether clinical equipoise regarding optimal treatment for patent ductus arteriosus (PDA) in prematurity is ...
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Open AccessPlatelets in pediatric and neonatal sepsis: novel mediators of the inflammatory cascade
Sepsis, a dysregulated host response to infection, has been difficult to accurately define in children. Despite a higher incidence, especially in neonates, a non-specific clinical presentation alongside a lack...
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Open AccessThe role of the calibrated automated thrombogram in neonates: describing mechanisms of neonatal haemostasis and evaluating haemostatic drugs
Premature infants are at high risk of haemorrhage and thrombosis. Our understanding of the differences between the neonatal and adult haemostatic system is evolving. There are several limitations to the standa...
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Cerebral oxygen saturation and autoregulation during hypotension in extremely preterm infants
The impact of the permissive hypotension approach in clinically well infants on regional cerebral oxygen saturation (rScO2) and autoregulatory capacity (CAR) remains unknown.
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A review of the role of extracellular vesicles in neonatal physiology and pathology
Extracellular vesicles (EVs) are cell-derived membrane-bound particles, extensively investigated across many fields to improve the understanding of pathophysiological processes, as biomarkers of disease and as...
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Patent ductus arteriosus shunt elimination results in a reduction in adverse outcomes: a post hoc analysis of the PDA RCT cohort
A post hoc appraisal of the PDA RCT to assess the relationship between early patent ductus arteriosus (PDA) shunt elimination and chronic lung disease or death (CLD/Death).
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Open AccessPrenatal prediction of neonatal haemodynamic adaptation after maternal hyperoxygenation
The reactivity of the pulmonary vascular bed to the administration of oxygen is well established in the post-natal circulation. The vasoreactivity demonstrated by the fetal pulmonary artery Doppler waveform in...
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The unintended consequences of acetaminophen use for ductal closure in premature infants
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Preventing disease in the 21st century: early breast milk exposure and later cardiovascular health in premature infants
Cardiovascular health of premature infants reaching early adulthood is an area of ongoing research. There is emerging evidence delineating the challenges faced by those individuals. Young adults born premature...
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Toward the elimination of bias in Pediatric Research
