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Article
Open AccessBuilding a predictive model of low birth weight in low- and middle-income countries: a prospective cohort study
Low birth weight (LBW, < 2500 g) infants are at significant risk for death and disability. Improving outcomes for LBW infants requires access to advanced neonatal care, which is a limited resource in low- and ...
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Article
Open AccessThe efficacy of low-dose aspirin in pregnancy among women in malaria-endemic countries
Low dose aspirin (LDA) is an effective strategy to reduce preterm birth. However, LDA might have differential effects globally, based on the etiology of preterm birth. In some regions, malaria in pregnancy cou...
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Article
Open AccessRegional trends in birth weight in low- and middle-income countries 2013–2018
Birth weight (BW) is a strong predictor of neonatal outcomes. The purpose of this study was to compare BWs between global regions (south Asia, sub-Saharan Africa, Central America) prospectively and to determin...
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Article
Open AccessAssociation of parity with birthweight and neonatal death in five sites: The Global Network’s Maternal Newborn Health Registry study
Nulliparity has been associated with lower birth weight (BW) and other adverse pregnancy outcomes, with most of the data coming from high-income countries. In this study, we examined birth weight for gestation...
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Open AccessMaternal mortality in six low and lower-middle income countries from 2010 to 2018: risk factors and trends
Maternal mortality is a public health problem that disproportionately affects low and lower-middle income countries (LMICs). Appropriate data sources are lacking to effectively track maternal mortality and mon...
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Article
Open AccessDevelopment of the Global Network for Women’s and Children’s Health Research’s socioeconomic status index for use in the network’s sites in low and lower middle-income countries
Socioeconomic status (SES) is an important determinant of health globally and an important explanatory variable to assess causality in epidemiological research. The 10th Sustainable Development Goal is to redu...
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Article
Open AccessThe relationship between birth intervals and adverse maternal and neonatal outcomes in six low and lower-middle income countries
Due to high fertility rates in some low and lower-middle income countries, the interval between pregnancies can be short, which may lead to adverse maternal and neonatal outcomes.
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Article
Open AccessStillbirth 2010–2018: a prospective, population-based, multi-country study from the Global Network
Stillbirth rates are high and represent a substantial proportion of the under-5 mortality in low and middle-income countries (LMIC). In LMIC, where nearly 98% of stillbirths worldwide occur, few population-bas...
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Article
Open AccessThe Global Network Maternal Newborn Health Registry: a multi-country, community-based registry of pregnancy outcomes
The Global Network for Women's and Children’s Health Research (Global Network) conducts clinical trials in resource-limited countries through partnerships among U.S. investigators, international investigators ...
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Article
Open AccessOligohydramnios: a prospective study of fetal, neonatal and maternal outcomes in low-middle income countries
Oligohydramnios is a condition of abnormally low amniotic fluid volume that has been associated with poor pregnancy outcomes. To date, the prevalence of this condition and its outcomes has not been well descri...
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Article
Open AccessPolyhydramnios among women in a cluster-randomized trial of ultrasound during prenatal care within five low and low-middle income countries: a secondary analysis of the first look study
In many low and low-middle income countries, the incidence of polyhydramnios is unknown, in part because ultrasound technology is not routinely used. Our objective was to report the incidence of polyhydramnios...
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Article
Open AccessFactors influencing referrals for ultrasound-diagnosed complications during prenatal care in five low and middle income countries
Ultrasound during antenatal care (ANC) is proposed as a strategy for increasing hospital deliveries for complicated pregnancies and improving maternal, fetal, and neonatal outcomes. The First Look study was a ...
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Open AccessSimplified antibiotic regimens for treating neonates and young infants with severe infections in the Democratic Republic of Congo: a comparative efficacy trial
One-quarter of neonatal and infant deaths are due to infection, and the majority of these deaths occur in develo** countries. Standard treatment for infection, which includes parenteral treatment only, is of...
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Article
Open AccessAnthropometric indices for non-pregnant women of childbearing age differ widely among four low-middle income populations
Maternal stature and body mass indices (BMI) of non-pregnant women (NPW) of child bearing age are relevant to maternal and offspring health. The objective was to compare anthropometric indices of NPW in four r...
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Open AccessA description of the methods of the aspirin supplementation for pregnancy indicated risk reduction in nulliparas (ASPIRIN) study
Preterm birth (PTB) remains the leading cause of neonatal mortality and long term disability throughout the world. Though complex in its origins, a growing body of evidence suggests that first trimester admini...
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Article
Open AccessRisk factors for maternal death and trends in maternal mortality in low- and middle-income countries: a prospective longitudinal cohort analysis
Because large, prospective, population-based data sets describing maternal outcomes are typically not available in low- and middle-income countries, it is difficult to monitor maternal mortality rates over tim...
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Article
Open AccessFirst look: a cluster-randomized trial of ultrasound to improve pregnancy outcomes in low income country settings
In high-resource settings, obstetric ultrasound is a standard component of prenatal care used to identify pregnancy complications and to establish an accurate gestational age in order to improve obstetric care...
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Article
Open AccessHome birth attendants in low income countries: who are they and what do they do?
Nearly half the world’s babies are born at home. We sought to evaluate the training, knowledge, skills, and access to medical equipment and testing for home birth attendants across 7 international sites.