-
Article
Energy metabolism and fertility—a balance preserved for female health
Metabolic and reproductive pathways are tightly associated, and this relationship has been conserved throughout evolution
- ...
-
Article
Global Profiling of TSEC Proliferative Potential by the Use of a Reporter Mouse for Proliferation
“Tissue-selective estrogen complex” or TSEC is a novel concept of estrogen replacement therapy for the postmenopause based on the combined use of estrogens and selective estrogen receptor modulators (SERMs). T...
-
Article
Silver paper: The future of health promotion and preventive actions, basic research, and clinical aspects of age-related disease
Background. In September 2008, under the French Presidency of the European Union and with the support of the Polish Minister of Health, a European Summit on Age-Related Disease was organi...
-
Protocol
Reporter Mice for the Study of Intracellular Receptor Activity
During the past decade the remarkable progress in molecular genetics and the possibility to engineer cells to express genes reporting on the activity of specific promoters has produced major changes in biologi...
-
Article
Development of a bicistronic vector for multimodality imaging of estrogen receptor activity in a breast cancer model: preliminary application
The aim of this study was to develop a cellular model for the concurrent imaging of reporter genes expression by using positron emission tomography (PET) and bioluminescence imaging (BLI) for the assessment of...
-
Chapter
Mechanisms of the Neuroprotective Effects of Estrogen
It is now well accepted that in mammals estrogen action extends far beyond the control of sexual functions. Apart from the regulation of reproductive functions and behavior, in fact, estrogen’s direct involvem...
-
Chapter
A Model System for the Study of Estrogen Receptor Activity in Cells of Neural Origin
For quite a long-time we have known that estrogens can modulate brain activities and estrogen receptors (ER) are present in a number of brain regions [1]. However, the study of the activity of estrogens in the...