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Open AccessKidney function measures and cardiovascular outcomes in people with diabetes: the Hoorn Diabetes Care System cohort
Both manifestations of kidney disease in diabetes, reduced eGFR (ml/min per 1.73 m2) and increased urinary albumin/creatinine ratio (UACR, mg/mmol), may increase the risk of specific CVD subtypes in adults with d...
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Open AccessReversal Of Arterial Disease by modulating Magnesium and Phosphate (ROADMAP-study): rationale and design of a randomized controlled trial assessing the effects of magnesium citrate supplementation and phosphate-binding therapy on arterial stiffness in moderate chronic kidney disease
Arterial stiffness and calcification propensity are associated with high cardiovascular risk and increased mortality in chronic kidney disease (CKD). Both magnesium and phosphate are recognized as modulators o...
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Article
Open AccessAlcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies
The causal effects of alcohol-in-moderation on cardiometabolic health are continuously debated. Mendelian randomization (MR) is an established method to address causal questions in observational studies. We pe...
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Open AccessMagnesium intake and vascular structure and function: the Hoorn Study
Circulating and dietary magnesium have been shown to be inversely associated with the prevalence of cardiovascular disease (CVD) and mortality in both high and low-risk populations. We aimed to examine the ass...
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Article
Open AccessCombined low vitamin D and K status amplifies mortality risk: a prospective study
To explore the association of both plasma vitamin D and K concentrations with all-cause mortality, cardiovascular mortality, and cardiovascular events in the general population.
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Open AccessNatriuretic peptides for the detection of diastolic dysfunction and heart failure with preserved ejection fraction—a systematic review and meta-analysis
An overview of the diagnostic performance of natriuretic peptides (NPs) for the detection of diastolic dysfunction (DD) and heart failure with preserved ejection fraction (HFpEF), in a non-acute setting, is cu...
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High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam
No previous study has evaluated the relationship between vitamin K and frailty. Thus, we assessed the relationship between vitamin K status and frailty over 13 years in the Longitudinal Aging Study Amsterdam (...
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Open AccessDaily sedentary time and physical activity as assessed by accelerometry and their correlates in older adults
Higher physical activity is associated with lower chronic disease risk among older adults. However, less is known about the optimal balance between daily physical activity and sedentary time and their correlat...
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Determinanten van vitamine D- gebruik door thuiswonende ouderen
Inzicht geven in de prevalentie van het vitamine D- gebruik en determinanten van vitamine D- gebruik bij thuiswonende ouderen vanaf 70 jaar.
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Role of Vitamin D in the Development of Insulin Resistance and Type 2 Diabetes
Vitamin D deficiency is mainly a consequence of insufficient sunlight induced vitamin D production in the skin and has been associated with various chronic diseases including type 2 diabetes. Experimental data...