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Article
Sex-related similarities and differences in responses to heart failure therapies
Although sex-related differences in the epidemiology, risk factors, clinical characteristics and outcomes of heart failure are well known, investigations in the past decade have shed light on an often overlook...
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Article
Open AccessUrinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction
Recent data suggest different causes of renal dysfunction between heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF). We therefore studied a wide range of urinary markers reflecting ...
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Article
Immunomodulation and immunopharmacology in heart failure
The immune system is intimately involved in the pathophysiology of heart failure. However, it is currently underused as a therapeutic target in the clinical setting. Moreover, the development of novel immunomo...
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Article
Open AccessNatriuresis-guided diuretic therapy in acute heart failure: a pragmatic randomized trial
Measurement of natriuresis has been suggested as a reliable, easily obtainable biomarker for assessment of the response to diuretic treatment in patients with acute heart failure (AHF). Here, to assess whether...
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Article
Open AccessSystemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure
Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol concentrations, as a marker of systemic oxidative stress, in HF ...
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Article
Open AccessPredictors of adverse diastolic remodeling in non-diabetic patients presenting with ST-elevation myocardial infarction
Adverse systolic remodeling after ST-elevation myocardial infarction (STEMI) is associated with poor clinical outcomes. However, little is known about diastolic remodeling. The purpose of this study was to ide...
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Article
Open AccessSexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease
Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food in...
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Article
Open AccessTranscatheter edge-to-edge repair of tricuspid regurgitation in the Netherlands: state of the art and future perspectives
Despite the high prevalence and adverse clinical outcomes of severe tricuspid regurgitation (TR), conventional treatment options, surgical or pharmacological, are limited. Surgery is associated with a high per...
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Article
Open AccessLeft atrial structure and function in heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF): systematic review and meta-analysis
Left atrial (LA) structure and function in heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF) is only established in small studies. Therefore, we conducted a systematic review of LA ...
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Article
Open AccessClinical impact of changes in mitral regurgitation severity after medical therapy optimization in heart failure
Few data are available regarding changes in mitral regurgitation (MR) severity with guideline-recommended medical therapy (GRMT) in heart failure (HF). Our aim was to evaluate the evolution and impact of MR af...
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Article
Open AccessThe SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial
The sodium–glucose cotransporter 2 inhibitor empagliflozin reduces the risk of cardiovascular death or heart failure hospitalization in patients with chronic heart failure, but whether empagliflozin also impro...
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Article
Open AccessCorrection to: The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure
The original article can be found online.
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Article
Drug development in oncology and devices—lessons for heart failure drug development and approval? a review
Heart failure (HF) and cancer are of the most common diseases globally, both associated with significant adverse outcomes and greatly impaired quality of life. Despite those similarities, over the last 15 year...
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Article
Open AccessA heart failure phenotype stratified model for predicting 1-year mortality in patients admitted with acute heart failure: results from an individual participant data meta-analysis of four prospective European cohorts
Prognostic models developed in general cohorts with a mixture of heart failure (HF) phenotypes, though more widely applicable, are also likely to yield larger prediction errors in settings where the HF phenoty...
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Article
Congestion in heart failure: a contemporary look at physiology, diagnosis and treatment
Congestion is the main reason for hospitalization in patients with acute decompensated heart failure and is an important target for therapy. However, achieving complete decongestion can be challenging. Further...
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Article
Open AccessTherapeutic approaches in heart failure with preserved ejection fraction: past, present, and future
In contrast to the wealth of proven therapies for heart failure with reduced ejection fraction (HFrEF), therapeutic efforts in the past have failed to improve outcomes in heart failure with preserved ejection ...
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Article
Open AccessHigher doses of loop diuretics limit uptitration of angiotensin-converting enzyme inhibitors in patients with heart failure and reduced ejection fraction
Loop diuretics are frequently prescribed to patients with heart failure and reduced ejection fraction (HFrEF) for the treatment of congestion; however, they might hamper uptitration of inhibitors of the renin–...
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Article
Open AccessThe influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure
In heart failure (HF), levels of NT-proBNP are influenced by the presence of concomitant atrial fibrillation (AF), making it difficult to distinguish between HF versus AF in patients with raised NT-proBNP. It ...
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Article
Open AccessGenome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) hav...
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Article
Open AccessPrognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation
In patients with heart failure with reduced ejection fraction (HFrEF) on sub-optimal doses of beta-blockers, it is conceivable that changes in heart rate following treatment intensification might be important ...
