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Article
Open AccessEpitope editing enables targeted immunotherapy of acute myeloid leukaemia
Despite the considerable efficacy observed when targeting a dispensable lineage antigen, such as CD19 in B cell acute lymphoblastic leukaemia1,2, the broader applicability of adoptive immunotherapies is hampered ...
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Article
Open AccessIntegrated metabolomic analysis and cytokine profiling define clusters of immuno-metabolic correlation in new-onset psoriasis
The association between the metabolic profile and inflammatory cytokines in psoriasis is poorly understood. We analyzed the metabolic and cytokine/chemokine profiles in serum and skin from patients with new-on...
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Article
A Contribution to the Harmonization of Non-targeted NMR Methods for Data-Driven Food Authenticity Assessment
Spectroscopic non-targeted methods are gaining ever-growing importance in quality control and authenticity assessment of food products because of their strong potential for identification of specific features ...
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Article
Open AccessField cancerization therapy with ingenol mebutate contributes to restoring skin-metabolism to normal-state in patients with actinic keratosis: a metabolomic analysis
Actinic keratosis (AK) is a skin premalignant lesion, which progresses into squamous cell carcinoma (SCC) if left untreated. Ingenol mebutate gel is approved for local treatment of non-hyperkeratotic, non-hype...
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Article
Baseline Studies of the Clay Minerals Society Source Clay Montmorillonite STx-1b
For more than forty years, The Clay Minerals Society has dispensed a set of source clays which have enabled a large number of researchers to work on similar materials. Many of these source clays remained uncha...
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Article
Lung surfactant metabolism: early in life, early in disease and target in cell therapy
Lung surfactant is a complex mixture of lipids and proteins lining the alveolar epithelium. At the air–liquid interface, surfactant lowers surface tension, avoiding alveolar collapse and reducing the work of b...
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Article
Erratum to: Changes in the NMR Metabolic Profile of Live Human Neuron-Like SH-SY5Y Cells Exposed to Interferon-α2
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Article
Assessment of freezing effects and diagnostic potential of BioBank healthy and neoplastic breast tissues through HR-MAS NMR spectroscopy
HR-MAS NMR spectroscopy was employed to monitor the metabolic profiles of Modena BioBank breast samples over 1 year of freezing at −80 °C. The study includes 22 adult female patients living in Modena and its h...
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Article
Open AccessUse of RNA interference to discover pathways involved in HIV infection and replication: cell lines tell many stories, primary cells might tell the truth
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Article
EPA or DHA Supplementation Increases Triacylglycerol, but not Phospholipid, Levels in Isolated Rat Cardiomyocytes
It is well recognized that a high dietary intake of long-chain polyunsaturated fatty acids (LC-PUFA) has profound benefits on health and prevention of chronic diseases. In particular, in recent years there has...
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Article
Characterization of a low-sulfated chondroitin sulfate from the body of Viviparus ater (mollusca gastropoda). Modification of its structure by lead pollution
A chondroitin sulfate was purified from the body of Viviparus ater (Mollusca gastropoda) and analyzed for molecular mass, constituent disaccharides, and structure by 1H NMR and 1H 2D NMR. A quite unique glycos...
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Article
The interaction of biliar acids with 2-hydroxypropyl-β-cyclodextrin in solution and in the solid state
The interaction of two biliar acids (chenodeoxycholic acid and cholic acid) with 2-hydroxypropyl-β-cyclodextrin (HPβCD) in solution and in the solid state was studied using different techniques. The formation of ...
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Article
Invertomers at nitrogen in aziridine carboxylates by mltltinuclear (1H,13C,17O, and15N) NMR study
A confrgurational and conformational study of NH, N-acetyl- and N-sulfonylaziridine carboxylates is performed by1H ,13C,17O, and15N NMR spectroscopy. The presence of acetyl and su fonyl groups on the ring nitroge...
