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Article
Open AccessInvasive vegetation encroachment modulates dual threats faced by island-endemic scaly crickets
The mechanisms by which non-native species impact island-endemic populations are varied and often convoluted. For effective invertebrate conservation where capacity is limited, it is vital to understand both d...
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Article
Open AccessTargeting myeloid chemotaxis to reverse prostate cancer therapy resistance
Inflammation is a hallmark of cancer1. In patients with cancer, peripheral blood myeloid expansion, indicated by a high neutrophil-to-lymphocyte ratio, associates with shorter survival and treatment resistance ac...
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The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells
Cancer is highly infiltrated by myeloid-derived suppressor cells (MDSCs). Currently available immunotherapies do not completely eradicate MDSCs. Through a genome-wide analysis of the translatome of prostate ca...
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Article
Open AccessUpregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth
Prostate cancer is the most common cancer in men and it is estimated that over 350,000 men worldwide die of prostate cancer every year. There remains an unmet clinical need to improve how clinically significan...
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Article
Open AccessAndrogen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer
Androgen receptor (AR) signalling is a key prostate cancer (PC) driver, even in advanced ‘castrate-resistant’ disease (CRPC). To systematically identify microRNAs (miRs) modulating AR activity in lethal diseas...
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Alternative splicing in prostate cancer
Androgen receptor (AR) splice variants (AR-Vs) have been implicated in the development and progression of metastatic prostate cancer. AR-Vs are truncated isoforms of the AR, a subset of which lack a ligand-bin...
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Article
IL-23 secreted by myeloid cells drives castration-resistant prostate cancer
Patients with prostate cancer frequently show resistance to androgen-deprivation therapy, a condition known as castration-resistant prostate cancer (CRPC). Acquiring a better understanding of the mechanisms th...
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Managing Metastatic Castration-Resistant Prostate Cancer in the Pre-chemotherapy Setting: A Changing Approach in the Era of New Targeted Agents
In recent years, the therapeutic options for treating men with metastatic castration-resistant prostate cancer have increased substantially. The hormonal treatments abiraterone acetate and enzalutamide, the ch...
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A phase 1b trial of the combination of an all-oral regimen of capecitabine and erlotinib in advanced non-small cell lung cancer in Caucasian patients
Erlotinib is active in advanced non-small cell lung cancer (aNSCLC) particularly in patients with EGFR-sensitizing mutations. The thymidylate synthase inhibitors are active in NSCLC, but capecitabine is not well...
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Open AccessFocused molecular analysis of small cell lung cancer: feasibility in routine clinical practice
There is an urgent need to identify molecular signatures in small cell lung cancer (SCLC) that may select patients who are likely to respond to molecularly targeted therapies. In this study, we investigate the...
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Content or technology? Technology every time
Marketers have been focusing on outputs that deliver an immediate impact, such as content and creative. But if marketing wants to take its rightful place at the boardroom table, it needs to look seriously at t...
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Open AccessText messaging as a community-based survey tool: a pilot study
It is not known whether using text messaging to administer real-time survey questions is feasible and acceptable among low-income, urban African American adults.
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The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription
BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets including heat-shock proteins and some nuclear hormone receptors. BAG-1 exists as three major isoforms, BAG-1L, BAG-1M an...
