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    Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism

    Checkpoint kinase 2 (Chk2) is the main effector kinase of ataxia telangiectasia mutated (ATM) and responsible for cell cycle regulation. ATM signaling has been shown to upregulate interferon-regulating factor-...

    Hajar Fahkri, Bingbing Zhang, Abul Fajol in Pflügers Archiv - European Journal of Phys… (2015)

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    Influence of annexin A7 on insulin sensitivity of cellular glucose uptake

    Insulin sensitivity is decreased by prostaglandin E2 (PGE2), a major product of cyclooxygenase (COX). As shown in erythrocytes, PGE2 formation is inhibited by annexin A7. The present study defined the role of ann...

    Dong Luo, Abul Fajol, Anja T. Umbach in Pflügers Archiv - European Journal of Phys… (2015)

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    Regulation of mineral metabolism by lithium

    Lithium, an inhibitor of glycogen synthase kinase 3 (GSK3), is widely used for the treatment of mood disorders. Side effects of lithium include nephrogenic diabetes insipidus, leading to renal water loss. Dehy...

    Hajar Fakhri, Ganesh Pathare, Abul Fajol in Pflügers Archiv - European Journal of Phys… (2014)

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    Article

    AMP-activated protein kinase regulates hERG potassium channel

    Besides their role in cardiac repolarization, human ether-a-go-go-related gene potassium (hERG) channels are expressed in several tumor cells including rhabdomyosarcoma cells. The channels foster cell prolifer...

    Ahmad Almilaji, Carlos Munoz, Bernat Elvira in Pflügers Archiv - European Journal of Phys… (2013)