5 Result(s)
within
Abhishek Satishchandran
English
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Article
Open AccessChronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations
Chronic alcohol consumption is associated with neuroinflammation, neuronal damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation is characterized by increased expression of ...
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Article
Open AccessReduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression
The end-organ effects of alcohol span throughout the entire body, from the gastrointestinal tract to the central nervous system (CNS). In the intestine, alcohol use changes the microbiome composition and incre...
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Article
Open AccessAlcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1α activation
Alcohol-related hepatocellular carcinoma (HCC) develops with advanced alcoholic liver disease and liver fibrosis. Using adult mice, we evaluate the effect of alcoholic steatohepatitis on early hepatobiliary ca...
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Article
Open AccessIncreased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis
It has been well documented that alcohol and its metabolites induce injury and inflammation in the liver. However, there is no potential biomarker to monitor the extent of liver injury in alcoholic hepatitis p...
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Article
Open AccessBiodistribution and function of extracellular miRNA-155 in mice
Circulating miRNAs can be found in extracellular vesicles (EV) and could be involved in intercellular communication. Here, we report the biodistribution of EV associated miR-155 using miR-155 KO mouse model. A...
