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Article
The Node of Ranvier as an Interface for Axo-Glial Interactions: Perturbation of Axo-Glial Interactions in Various Neurological Disorders
The action potential conduction along the axon is highly dependent on the healthy interactions between the axon and myelin-producing glial cells. Myelin, which facilitates action potential, is the protective i...
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Chapter
Drug Delivery Systems to the Peritoneum: Current Status and Future Perspectives
Intraperitoneal drug delivery systems provide a regional therapy model for the peritoneal and also relatively increase the half-life and concentration of the desired drug molecule in the peritoneum cavity. Cur...
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Chapter
Emerging Applications of Nanotechnology in Human Welfare with Special Reference to Biomedical Issues
Nanotechnology has attracted researchers from diverse fields due to its outstanding potential in providing solutions to current-day problems. It deals with structures that are typically less than 100 nm at lea...
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Article
Measuring activation depth profiles in very highly doped ultra-thin semiconductors at sub-nm depth resolution
The value of depth profiling the electrical parameters in ion-implanted shallow junctions was demonstrated using Differential Hall Effect Metrology (DHEM) technique. Two samples were prepared in Si wafers with...
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Article
Polymeric magnetic nanoparticles: a multitargeting approach for brain tumour therapy and imaging
The most challenging task in targeting the brain is trespassing the blood–brain barrier (BBB) which restricts the movement of about 98% small molecules. Targeting the central nervous system using magnetic nano...
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Article
Annealing effects on electrical property depth profiles of BF2 and P implanted polycrystalline Si determined by differential hall effect metrology
Differential Hall effect metrology (DHEM) was used to accurately and effectively evaluate the carrier concentration, mobility, and resistivity depth profiles at nano-scale resolution for BF2 and P implanted poly-...
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Chapter
Point-of-Care Biosensors for Glucose Sensing
Glucose is the primary energy source in humans that circulates in the blood and provides energy to the entire body. A change in the blood glucose level leads to various disorders, like hypoglycemia and hypergl...
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Protocol
In Vitro Models of Central Nervous System Barriers for Blood-Brain Barrier Permeation Studies
One of the biggest challenging diseases are the neurodegenerative diseases which are not easy to target due to the presence of a complex semipermeable, dynamic, and adaptable barrier between the central nervou...
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Article
A novel biosensor for the detection of organophosphorus (OP)-based pesticides using organophosphorus acid anhydrolase (OPAA)-FL variant
Indiscriminate use of organophosphorus (OP)-based insecticides is a great concern to human health because of bioaccumulation-induced health hazards. Potentially fatal consequences and limited treatment methods...
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Article
Open AccessUltrasonic atomizer based development of pH sensor for real time analysis
Fluorescent pH biosensors have gained importance owing to their low cost utilization in real time monitoring of biological and food samples in comparison to conventional pH meters. The research reports a novel...
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Article
Open AccessMap** axon initial segment structure and function by multiplexed proximity biotinylation
Axon initial segments (AISs) generate action potentials and regulate the polarized distribution of proteins, lipids, and organelles in neurons. While the mechanisms of AIS Na+ and K+ channel clustering are unders...
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Article
Open AccessAnalysis of critical drivers affecting implementation of agent technology in a manufacturing system
Technological advancement in the manufacturing system in current scenario is inevitable due to today’s customer-driven and volatile nature of the market. Implementation of agent technology in a manufacturing s...
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Article
Open AccessFluorescent Biocompatible Platinum-Porphyrin–Doped Polymeric Hybrid Particles for Oxygen and Glucose Biosensing
Near infrared (NIR) fluorophores like Pt-porphyrin along with analyte specific enzymes require co-encapsulation in biocompatible and biodegradable carriers in order to be transformed into implantable biosensor...
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Chapter
Biomedical Instrumentation: Focus Toward Point-of-Care Devices
Biomedical instrumentation (BMI) deals with the measuring, recording, and transmitting biological signals from and to the human body to enable development of new algorithms and instruments to solve health-rela...
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Article
Open AccesspH and Urea Estimation in Urine Samples using Single Fluorophore and Ratiometric Fluorescent Biosensors
Kidney diseases remain often undiagnosed due to inefficient screening methods available at patient’s disposal. Early diagnosis and effective management of kidney problems can best be addressed by the developme...
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Article
Impact of Age and Polytherapy on Fingolimod Induced Bradycardia: a Preclinical Study
Fingolimod is a an oral disease modifying drug for relapsing remitting multiple sclerosis (MS) preventing egress of B and T cells from lymph nodes. Relevant first dose adverse events include bradycardia and at...
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Chapter
Targeted Drug Delivery for Personalized Cure
Human population bears a similarity to an extent of 99.9%, however mere 0.1% of variability also creates large differences in personal make-up owing to several hereditary and environmental factors. Conventiona...
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Chapter
On-Demand Controlled Drug Delivery
Spatial and temporal control of drug delivery is of prime importance for establishing the therapeutic compliance of drugs for various diseases. Conventional approaches to drug delivery for temporal control of ...
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Article
New Dosage Formulations for Targeted Delivery of Cyclo-Oxygenase-2 Inhibitors
NSAIDS are a widely used class of analgesic and anti-inflammatory drugs that act by inhibiting the cyclo-oxygenase (COX) enzyme. However, because of their nonspecificity of action, use of these agents as long-...
