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Article
Open AccessBreast cancer treatment and its impact on survival in Morocco: a study over a decade
In Morocco, much progress has been made in breast cancer treatment. However, there is limited information on survival outcomes of breast cancer patients according to their therapeutic management.
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Open AccessEvolution of patterns of care for women with cervical cancer in Morocco over a decade
We conducted a Pattern-of-care (POC) study at two premier-most public-funded oncology centers in Morocco to evaluate delays in care continuum and adherence to internationally accepted treatment guidelines of c...
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Open AccessBody image dissatisfaction and lower self-esteem as major predictors of poor sleep quality in gynecological cancer patients after surgery: cross-sectional study
Sleep quality is among the indicators associated with the quality of life of patients with cancer. A multitude of factors may affect patient sleep quality and are considered as associated predictive factors. T...
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Article
Extended healthy lifestyle index and colorectal cancer risk in the Moroccan population
Little is known about the combined effect of different lifestyle factors on CRC incidence among populations living in develo** countries. In this study, we sought to create an Extended Healthy Lifestyle Inde...
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Article
Open AccessCirculating cell‐free epstein–barr virus DNA levels and clinical features in Moroccan patients with nasopharyngeal carcinoma
The identification of effective prognosis biomarkers for nasopharyngeal carcinoma (NPC) is crucial to improve treatment and patient outcomes. In the present study, we have attempted to evaluate the correlation...
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Article
Risk factors for inflammatory and non-inflammatory breast cancer in North Africa
Studies of the etiology of inflammatory breast cancer (IBC), a rare but aggressive breast cancer, have been hampered by limited risk factor information. We extend previous studies by evaluating a broader range...
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Article
Open AccessPrimary neuroendocrine tumors of the breast: two case reports and review of the literature
Neuroendocrine carcinomas mainly affect the bronchopulmonary and the gastrointestinal systems. Breast localizations are very rare. They represent less than 0.1% of all breast cancers. A definitive diagnosis re...
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Association of Variants in IL6-Related Genes with Lung Cancer Risk in Moroccan Population
Lung cancer is known to be a complex multifactorial disease, involving both genetic and environmental factors. The study of the different signaling pathways and the identification of the genes involved, will c...
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Article
Clinico-pathologic and mammographic characteristics of inflammatory and non-inflammatory breast cancer at six centers in North Africa
We describe the clinico-pathologic and mammographic characteristics of inflammatory breast cancer (IBC) and non-IBC cases enrolled in a case–control study. Because IBC is a clinico-pathologic entity with rapid...
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Article
Open AccessNo association between TGF-β1 polymorphisms and risk of nasopharyngeal carcinoma in a large North African case-control study
Genetic susceptibility plays a key role in the development of nasopharyngeal carcinoma (NPC) and in fact the disease presents with an unusually high incidence in certain regions of the world like North Africa....
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Open AccessQuality of life of early stage colorectal cancer patients in Morocco
A multicentre cohort study was held in Morocco, designed to evaluate the quality of life of cancer patients. The aim of this paper is to report the assessment of the quality of life of early colorectal cancer ...
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Article
Open AccessAssociation between ABCB1 C3435T polymorphism and breast cancer risk: a Moroccan case-control study and meta-analysis
Breast cancer is the most common cause of cancer death among women. Several studies have investigated the relationship between the C3435T polymorphism of ABCB1 gene and risk of breast cancer; but the results a...
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Open AccessClinical and pathological features of BRCA1/2 tumors in a sample of high-risk Moroccan breast cancer patients
BRCA1 and BRCA2 genes explain a large part of hereditary breast cancer. Several studies have shown that BRCA1 and BRCA2 tumors exhibit some specific morphological and immunohistochemic...
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Article
Open AccessScreening of exon 11 of BRCA1 gene using the high resolution melting approach for diagnosis in Moroccan breast cancer patients
Identification of specific mutations in cancer patients may lead to the discovery of genes, which can affect susceptibility and/or prognosis. It has previously been reported that mutations in BRCA1 and BRCA2 gene...
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Article
Open AccessThe CHEK2 1100delC allelic variant is not present in familial and sporadic breast cancer cases from Moroccan population
The cell-cycle checkpoint kinase 2 (CHEK2) is an important signal transducer of cellular responses to DNA damage, whose defects has been associated with increased risk for breast cancer. The CHEK2 1100delC mut...
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Article
Open AccessFive years of local control of subscapularis aggressive fibromatosis managed by surgery and imatinib: a case report
Imatinib, a tyrosine kinase inhibitor, is a major therapeutic option for the management of unresectable aggressive fibromatosis. Unfortunately, for most patients of low or very low average income countries, su...
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Article
Association of TP53 PIN3 polymorphism with breast cancer in Moroccan population
TP53 is a tumor suppressor gene involved in cell cycle progression control, DNA damage repair, genomic stability, and apoptosis. Some polymorphisms in this gene have been associated with the development of a n...
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Article
Open AccessAnalysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women
Worldwide, cervical cancer is the second most common cancer in women. High-risk human papillomavirus (HPV) play a crucial role in the etiology of cervical cancer and the most prevalent genotype is HPV16. HPV 1...
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Open AccessEnvironmental, genetic and viral risk factors of nasopharyngeal carcinoma in North Africa
