125 Result(s)

Reference Work Entry In depth

Adrenomedullin/Intermedin

A. J. Clark, G. Ladds in Encyclopedia of Molecular Pharmacology (2021)

Living Reference Work Entry In depth

Adrenomedullin/Intermedin

A. J. Clark, G. Ladds in Encyclopedia of Molecular Pharmacology

Chapter and Conference Paper

Collaborative Geospatial Data as Applied to Disaster Relief: Haiti 2010

The aftermath of Haiti’s January 12 earthquake typified disaster relief in that efficiency and situational awareness were reduced by the chaotic, uncoordinated influx of relief and aid. The lack of an environm...

A. J. Clark, Patton Holliday, Robyn Chau… in Security Technology, Disaster Recovery and… (2010)

Article

Prognosis in DNA Mismatch Repair Deficient Colorectal Cancer: are all MSI Tumours Equivalent?

Microsatellite instability (MSI) in colorectal tumours is the hallmark of defective DNA mismatch repair (MMR) and high level MSI can be detected in up to 15% of incident colorectal cancers. MSI in sporadic col...

A. J. Clark, R. Barnetson, S. M. Farrington, M. G. Dunlop in Familial Cancer (2004)

Article

Lead Poisoning in Upland-foraging Birds of Prey in Canada

We examined the degree of lead exposure, based on tissue-lead concentrations, in 184 raptors of 16 species found dead across Canada. The most prevalent species available for examination were Red-tailed hawks, ...

A.J. Clark, A.M. Scheuhammer in Ecotoxicology (2003)

Chapter

Optimisation of Transgene Expression in the Mammary Gland

C. B. A. Whitelaw, A. J. Clark in Animal Cell Technology: Basic & Applied Aspects (2002)

Article

Deletion of the α(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep

Nuclear transfer offers a cell-based route for producing precise genetic modifications in a range of animal species. Using sheep, we report reproducible targeted gene deletion at two independent loci in fetal ...

C. Denning, S. Burl, A. Ainslie, J. Bracken, A. Dinnyes… in Nature Biotechnology (2001)

Article

The RadB protein from Pyrococcus does not complement E. coli recA mutations in vivo

A previous publication claimed that the radB gene called Pk-REC from Pyrococcus furiosus complemented an E. coli recA mutation. We found that a sequencing error had led to the test of a mutant form of Pk-REC. Th...

W. Inwood, S. Kane, J. DiRuggiero, F. Robb, A.J. Clark in Molecular Genetics and Genomics (2001)

Article

Deletion of The Gene Encoding H-FABP/MDGI has no Overt Effects in The Mammary Gland

Heart fatty acid binding protein (H-FABP) is expressed abundantly in the mammary gland. A number of in vitro studies have shown that H-FABP is functionally indistinguishable from a factor isolated from this organ...

A.J. Clark, C. Neil, B. Gusterson, J. McWhir, B. Binas in Transgenic Research (2000)

Article

Gene targeting in livestock: a preview

Until recently genetically modified livestock could only be generated by pronuclear injection. The discovery that animals can be cloned by nuclear transfer from cultured somatic cells means that it will now be...

A.J. Clark, S. Burl, C. Denning, P. Dickinson in Transgenic Research (2000)

Article

How Wind Affects the Photosynthetic Performance of Trees: Quantified with Chlorophyll a Fluorescence and Open-Top Chambers

Meteorological parameters inside and outside an open-top chamber (OTC) fumigation facility were recorded and the primary photosynthetic response of four tree species measured with chlorophyll (Chl) a fluorescence...

A.J. Clark, W. Landolt, J.B. Bucher, R.J. Strasser in Photosynthetica (2000)

Article

Responses of Young Trees (Five Species in a Chamber Exposure) to Near-Ambient Ozone Concentrations

This investigation is intended to add to the quantitative information about the sensitivity of European deciduous tree species to environmentally realistic ozone (O₃) exposure in respect to the established critic...

M.S. Günthardt-Goerg, S. Maurer, J. Bolliger, A. J. Clark… in Water, Air, and Soil Pollution (1999)

Article

Nitroreductase-mediated cell ablation is very rapid and mediated by a p53-independent apoptotic pathway

Nitroreductase (NTR)-mediated selective cell ablation using the prodrug CB1954 has been achieved in vivo by targeting the nitroreductase gene to the luminal cells of the mammary gland in transgenic mice. We re...

W Cui, B Gusterson, A J Clark in Gene Therapy (1999)

Chapter

Responses of Young Trees (Five Species in a Chamber Exposure) to Near-Ambient Ozone Concentrations

This investigation is intended to add to the quantitative information about the sensitivity of European deciduous tree species to environmentally realistic ozone (O₃) exposure in respect to the established critic...

M. S. Günthardt-Goerg, S. Maurer… in Forest Growth Responses to the Pollution C… (1999)

Article

Red clover mottle virus from Ukraine is an isolate of RCMV strain S

The relationship between red clover mottle virus (RCMV) isolated in the Ukraine (designated RCMV-Uk) and well-characterised strains from Sweden has been investigated. Nucleic acid hybridisation indicate that b...

L.G. Lapchic, A.J. Clark, G.P. Lomonossoff… in European Journal of Plant Pathology (1998)

Chapter

Molecular Analysis of the Polygalacturonase-Inhibiting Protein (PGIP) Gene Family in Phaseolus Vulgaris L.

In Phaseolus vulgaris (bean), PGIP is encoded by a gene family. We have isolated cDNA clones corresponding to two different pgip genes (pgip-1 and pgip-2). These genes have been separately expressed in Nicotiana ...

F. Cervone, G. De Lorenzo, B. Aracri… in Molecular Genetics of Host-Specific Toxins… (1998)

Article

Developmental and pathogen-induced accumulation of transcripts of polygalacturonase-inhibiting protein in Phaseolus vulgaris L.

Expression of the polygalacturonase-inhibiting-protein gene ( pgip) during development of French bean (Phaseolus vulgaris L. cv. Red Kidney) was analysed in various organs, including leaves, stems and roots of e...

A. Devoto, A. J. Clark, L. Nuss, F. Cervone, G. De Lorenzo in Planta (1997)

Article

Comparable processing ofβ-lactoglobulin pre-mRNA in cell culture and transgenic mouse models

Eukaryotic pre-mRNAs undergo a variety of post-transcriptional modifications, including the removal of intronic sequences by splicing, leading to creation of a functional mRNA. We have compared the processing ...

G. Donofrio, A. J. Clark, C. B. A. Whitelaw… in Molecular and General Genetics MGG (1996)