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EAST-Syndrom
Die Erforschung seltener Erkrankungen ermöglicht häufig entscheidende Erkenntnisse über die Pathophysiologie des Menschen. Kürzlich haben wir ein neues Krankheitsbild bei Kindern beschrieben, welches mit einem...
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Article
The role of KCNQ1/KCNE1 K+ channels in intestine and pancreas: lessons from the KCNE1 knockout mouse
KCNE1 (IsK, minK) co-assembles with KCNQ1 (KvLQT1) to form voltage-dependent K+ channels. Both KCNQ1 and KCNE1 are expressed in epithelial cells of gut and exocrine pancreas. We examined the role of KCNQ1/KCNE1 ...
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Article
Chloride channels in the luminal membrane of rat pancreatic acini
Pancreatic acini secrete Na+, Cl–and H2O in response to secretagogues such as acetylcholine. Cl–channels in the luminal membrane are a prerequisite for this secretion. The properties of the corresponding conduct...
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Article
Whole-cell conductive properties of rat pancreatic acini
Acetylcholine-controlled exocrine secretion by pancreatic acini has been explained by two hypotheses. One suggests that NaCl secretion occurs by secondary active secretion as has been originally described for ...