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  1. Article

    Open Access

    An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations

    Meckel syndrome (MKS) is an inherited autosomal recessive hepatorenal fibrocystic syndrome, caused by mutations in TMEM67, characterized by occipital encephalocoele, renal cysts, hepatic fibrosis, and polydactyly...

    C. Stayner, C. A. Poole, S. R. McGlashan, M. Pilanthananond… in Scientific Reports (2017)

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  2. No Access

    Article

    International variations in application of the best-interest standard across the age spectrum

    Ethically and legally, assertions that resuscitation is in a patient’s best interest should be inversely correlated with willingness to forego intensive care (and accept comfort care) at the surrogate’s reques...

    N Laventhal, A A E Verhagen, T W R Hansen, E Dempsey, P G Davis… in Journal of Perinatology (2017)

  3. No Access

    Article

    The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2

    A number of naturally occurring isoforms of the tumour suppressor protein p53 have been discovered, which appear to have differing roles in tumour prevention or promotion. We are investigating the tumour-promo...

    I Roth, H Campbell, C Rubio, C Vennin, M Wilson, A Wiles, G Williams, A Woolley… in Oncogene (2016)

  4. Article

    Open Access

    Primary cilia defects in the polycystic kidneys from an ovine model of Meckel Gruber syndrome

    T Poole, C Stayner, SR McGlashan, K Parker, A Wiles, M Jennings, CG Jensen… in Cilia (2012)

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  5. No Access

    Article

    p53 promotes adenoviral replication and increases late viral gene expression

    The tumor suppressor protein, p53, plays a critical role in viro-oncology. However, the role of p53 in adenoviral replication is still poorly understood. In this paper, we have explored further the effect of p...

    J A Royds, M Hibma, B R Dix, L Hananeia, I A Russell, A Wiles, D Wynford-Thomas… in Oncogene (2006)

  6. No Access

    Chapter

    Regulation and Multiplicity of Peptide Transporters in Model Systems

    The ability for organisms to engage in carrier-mediated transport of small peptides (2–5 amino acids) is ubiquitous. Peptide transporters with obvious structural similarities have been documented in bacteria, ...

    Jeffrey M. Becker, V. Narita, A. Wiles, M. Hauser… in Peptides: The Wave of the Future (2001)

  7. No Access

    Article

    On ordinary λ-adic representations associated to modular forms

    A. Wiles in Inventiones mathematicae (1988)

  8. No Access

    Article

    Class fields of abelian extensions of Q

    B. Mazur, A. Wiles in Inventiones mathematicae (1984)

  9. No Access

    Article

    On the conjecture of Birch and Swinnerton-Dyer

    J. Coates, A. Wiles in Inventiones mathematicae (1977)