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Article
Effect of Prenatal Hypoxia on Activity of the Soluble Forms of Cholinesterases in Rat Brain Structures during Early Postnatal Ontogenesis
The dynamics of soluble AChE and BChE (EC 3.1.1.7; EC 3.1.1.8) in the hippocampus, cortex, cerebellum and blood serum of control rats and rats exposed to prenatal hypoxia was studied on days 5, 10 and 30 of po...
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Article
Features of the Aggregation of С70 Fullerene in an o-Xylol Solution Revealed by the Dynamic Light Scattering Method
Features of the aggregation of С70 fullerene in an o-xylol have been revealed by observing the Doppler shift as a nondiffusive component in the dynamic light scattering spectra. The Doppler shift is proportional ...
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Article
Antioxidant Properties of Fullerene C60/Dihydroquercetin Composites
A complex of fullerene C60 and dihydroquercetin (DHQC) was synthesized. Its biological activity in a model system was studied using chemiluminometry. It was established that the C60/DHQC complex possessed antioxi...
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Article
Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny
Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content ...
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Article
On the role of biogenic amines and reactive oxygen species in the disruption of the hypothalamic regulation of reproductive function in xenobiotic-induced and experimental hyperhomocysteinemia
This review describes the role of biogenic amines in the hypothalamic regulation of ovarian cycles in female rats. The mechanisms of action of industrial xenobiotics and experimental hyperhomocysteinemia, whic...
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Article
Indices of oxidative stress in the brain of newborn rats subjected to prenatal hyperhomocysteinemia
We studied the influence of hyperhomocysteinemia (HHC), which was induced in rats during pregnancy by a methionine load, on the indices of free-radical oxidation and antioxidant defense (AOD) in the brains of ...
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Article
Age-related impairment of hypothalamic regulation of the reproductive cycle and its correction
In this review the modern conceptions about the neuroendocrine regulation of senescence of the female organism’s reproductive system are presented. Published data suggesting the leading role of the hypothalamu...
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Article
New approaches to stabilization of oxidation of lipid micellar systems with biologically active oligopeptides
The character of influence on oxidation for different ways of initiation of a series of oligopeptides was studied in an in vitro system: vilon (Lys—Glu) (1), vezugen (Lys—Glu—Asp) (2), pinealon (Glu—γ-Asp—δ-Arg) ...
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Article
Pinealon corrects hyperhomocysteinemia-induced disturbances of the diurnal dynamics of hypothalamic norepinephrine content in female rats
The effect of experimental hyperhomocysteinemia on diurnal dynamics of norepinephrine content in the medial preoptic area of the female rat hypothalamus, which is responsible for the synthesis of gonadotropin-...
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Article
Age-related changes in 6-hydroxymelatonin sulfate excretion in patients with gastric and colorectal cancer
The age-related dynamics of 6-hydroxymelatonin sulfate (6-OHMS) excretion was studied in 175 patients with gastric (89 patients) and colorectal cancer (86 patients). An age-related decrease in 6-OHMS excretion...
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Article
The use of different experimental models of hyperhomocysteinemia in neurochemical studies
We reviewed experimental models in which an increase in the content of homocysteine in rat blood was achieved by chronic (1 month) consumption of methionine with drinking water (1 g/kg weight) or forced oral i...
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Article
The determination of chemiluminescence intensity in an experimental model of premature senescence
The diagnostic abilities of chemiluminescence intensity investigations for the prognosis of premature senescence are discussed. The determination of chemiluminiscence intensity makes it possible to reveal indi...
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Article
Verification of a decrease in the rigidity of the phage λ DNA polymeric chain in low ionic strength aqueous solutions by testing the polymer-polymer interlink interactions
Changes in the rigidity of the polymeric chain of phage λ double-strand DNA have been studied by laser correlation spectroscopy. It was shown that, as the ionic strength increases, the effect of the screening ...
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Article
Effects of melatonin and epiphysis peptides on the catecholamine link of hypothalamic regulation of the reproductive function of rats
We studied the effects of melatonin and epiphysis peptides (epithalamin and epitalon) on the daily dynamics of the content of noradrenalin (NA) in the medial preoptic area (MPA) and dopamine (DA) in the median...
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Article
Fluorescent Microscopic Study of Epithalon Binding in Maternal and Fetal Rabbit Tissues in Health and under Conditions of Placental Insufficiency
Epithalon (regulatory tetrapeptide) labeled with dansil (fluorescent stain) easily penetrates into all tissues and organs of pregnant rabbit females and through the placenta into fetal organs. Incorporation of...
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Article
Asymmetry of Motor Behavior of the Goldfish in a Narrow Channel
We studied swimming of goldfish fries about 3 cm long in a narrow channel by calculating the numbers of spontaneous turns on different sides. The ratio of fishes preferring to turn to the right vs to the left was...
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Article
Glutathione-Dependent System of Antioxidant Defense in the Placenta in Preterm Delivery
Components of the antioxidant defense system in placental tissues were studied in women with normal pregnancy and full-term delivery and women with spontaneous abortions at 28-36 weeks. In women with spontaneo...
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Article
Effect of Chronic Inhalation of Toluene and Dioxane on Activity of Free Radical Processes in Rat Ovaries and Brain
The effects of toluene and dioxane inhalations on the intensity of free radical oxidation in rat ovaries and brain cortex were studied. Both toxins in a dose 10-fold surpassimg the maximum permissible concentr...
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Article
Effects of Peptides on Generation of Reactive Oxygen Species in Subcellular Fractions of Drosophila Melanogaster
We studied the effects of Epithalon (Ala-Glu-Asp-Gly) and Vilon (Lys-Glu) on free radical processes in highly inbred HA+line of Drosophila melanogaster. Vilon inhibited generation of reactive oxygen species in mi...
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Article
The Effects of Thyroxine Isomers on Free-Radical Oxidation Processes in Subcellular Fractions of Rat Cerebral Cortex
Measurements made by chemiluminescence (CL) were used to estimate effective D- and L-thyroxine concentrations and to study their effects on free-radical oxidation processes in the mitochondrial and synaptosoma...
