-
Article
Accelerated Aging as a Risk of Education Digitalization: Possibilities for Prevention
The work is devoted to analyzing the negative effects of digitalizing education and considering the possibilities for their prevention. The urgency of this problem under the current conditions of combating the...
-
Article
The Effect of Hyperhomocysteinemia on the Content of Neurotrophins in Brain Structures of Pregnant Rats
Abstract—Maternal hyperhomocysteinemia (HHC) during pregnancy was shown to lead to disruption of fetal nervous system development and cause long-term consequences, including cognitive dysfunction, in postnatal li...
-
Article
Neuroprotective Potential of Creatine. Hidden Resources of Its Therapeutic and Preventive Use
Abstract—The relevant scientific literature has accumulated an extensive array of data indicating the neuroprotective potential of creatine (Cr). However, while many recent experimental and clinical studies confi...
-
Article
Maternal Hyperhomocysteinemia Induces Neuroinflammation and Neuronal Death in the Rat Offspring Cortex
Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyp...
-
Article
Influence of Prenatal Hypoxia on the Content of Neuron Specific Enolase in the Structures of the Brain and Blood Serum of Rats in Early Ontogeny
Abstract—We studied the dynamics of changes in the content of neuron specific enolase (NSE, EC 4.2.1.11) in the hippocampus, cortex, cerebellum and blood serum of rats at 5th, 10th, and 30th days of postnatal dev...
-
Article
Neurotrophins of the Fetal Brain and Placenta in Prenatal Hyperhomocysteinemia
Prenatal hyperhomocysteinemia (PHHC) in pregnant rats was induced by chronic L-methionine loading, resulting in a significant increase in the L-homocysteine content both in the mothers’ blood and blood and bra...
-
Article
Role of Caspases in the Cytotoxicity of NK-92 Cells in Various Models of Coculturing with Trophoblasts
Studies of interactions between natural killer (NK) cells and trophoblasts and identification of conditions for the NK cells to perform their cytotoxic function are of fundamental and practical importance for ...
-
Article
The Role of Melatonin in Morphofunctional Development of the Brain in Early Ontogeny
Abstract—This review summarizes the current understanding of the regulatory role of melatonin in the formation of the nervous system in the antenatal and early postnatal period of body development. We discuss que...
-
Article
The Dynamics of the Contents of Neurotrophic Factors in Early Ontogeny in the Brain Structures of Rats Subjected to Prenatal Hypoxia
We analyzed the contents of neurotrophic factors (BDNF and NGF) and the S-100 protein in the hippocampus, cortex, and cerebellum of the rat brain during early postnatal ontogeny. We found that the BDNF content...
-
Article
The effects of prenatal hyperhomocysteinemia on the formation of memory and the contents of biogenic amines in the rat hippocampus
We evaluated the long-term neurophysiological effects of prenatal hyperhomocysteinemia (HHC) in mature female rats whose mothers received an oral methionine load daily from the fourth day of pregnancy to deliv...
-
Article
Melatonin as a marker of severity of cardiac disorders in develo** cachexia syndrome among cancer patients of different age groups
We investigated 103 newly diagnosed stage II–IV cancer patients aged 28–78 years before the beginning of their anticancer therapy. The signs of cachexia syndrome were diagnosed and staged (precachexia or fully...
-
Article
Age-related changes in biogenic amine content and oxidative stress profile in rat hypothalamus with hyperhomocysteinemia
The article presents a detailed analysis of correlations between the content of a variety of biogenic amines in the hypothalamic structures responsible for the gonadotropin-releasing hormone synthesis and secr...
-
Article
The protective effect of melatonin and epithalon on hypothalamic regulation of the reproductive function in female rats in a model of its premature aging and on the estrous cycles of aging animals in different lighting conditions
Possible neuroprotective effects of melatonin (pineal gland hormone) and epithalon (peptide preparation) on estrous cycles and the central part of the reproductive function regulation in female rats under the ...
-
Article
Effects of geroprotective peptides on the activity of cholinesterases and formation of the soluble form of the amyloid precursor protein in human neuroblastoma SH-SY5Y cells
Age related decline of cognitive functions in humans is a result of degeneration of cholinergic neurones and acetylcholine deficit in certain brain structures. In this connection, inhibitors of cholinesterases...
-
Article
Activity of monoamine oxidase in the medial preoptic area and median eminence of female rats of different ages
Total monoamine oxidase activity in the medial preoptic area and median eminence (with surrounding tissue) has been studied in female rats of three age groups, viz., those aged 1.5–2 months (peripubertal), 4–5...
-
Article
Regulatory peptides protect brain neurons from hypoxia in vivo
-
Article
Monoamine oxidase activity in several structures of rat brain
Spectrophotometric detection (at 327 nm) of a product of the kynuramine oxidation was used to study the distribution of the total activity of monoamine oxidase (MAO) in the hypothalamus, limbic system, dorsal ...
-
Chapter
BB-Isoform of Creatine Kinase in Amniotic Fluid as a Marker of Brain Development Disorders
Creatine kinase is one of the main enzymes of the energy metabolism. It also carries out a bioregulative function and is very sensitive to changes in the functional state of an organism. There are three cytopl...
-
Chapter
The Disturbances of the Hypothalamic Circadian Rhythm Regulation in Female Rats Under the Influence of Xenobiotics
The reproductive system is one of the most sensitive systems of the organism that reacts on environmental pollution. Former experiments (1,2) led to the conclusion that independent of nature ecologically unfav...
