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Article
Erratum: The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways
Correction to: Oncogene (2008) 27, 4557–4568; doi:10.1038/onc.2008.90; published online 14 April 2008 Since the publication of the above paper, the authors found inadvertent errors and mislabelings in Figures ...
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Article
The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways
The molecular causes for resistance of melanoma to apoptosis are currently only partly understood. In the present study, we examined gene transfer and expression of the proapoptotic BH3-only protein Noxa as an...
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Article
Basement membrane component laminin-5 is a target of the tumor suppressor Smad4
The tumor suppressor Smad4 is involved in carcinogenesis mainly of the pancreas and colon. Functional inactivation of Smad4 is a genetically late event that occurs upon transition from premalignant stages to i...
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Article
Evaluation of potential mechanisms underlying genotype–phenotype correlations in multiple endocrine neoplasia type 2
Distinct dominant activating mutations in the RET proto-oncogene are responsible for the development of multiple endocrine neoplasia type 2 (MEN 2). Concise examination of the mutated codons led to the detection ...
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Article
TAp73/ΔNp73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma
We investigated the mechanisms by which TAp73β and dominant-negative p73 (ΔNp73) regulate apoptosis. TAp73β transactivated the CD95 gene via the p53-binding site in the first intron. In addition, TAp73β induced e...
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Article
Increased ΔN-p73 expression in tumors by upregulation of the E2F1-regulated, TA-promoter-derived ΔN′-p73 transcript