5 Result(s)
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Article
Open AccessStem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition
Inhibitors of the mechanistic target of rapamycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive phenotype is sustained through adaptation or resistance to...
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Article
Open AccessBreast cancer brain metastases: a review of the literature and a current multidisciplinary management guideline
Breast cancer represents the second most frequent etiology of brain metastasis (BM). It is estimated that 10–30 % of patients with breast cancer are diagnosed with BM. Breast cancer BM are increasing due to th...
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Article
Erratum: Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs
Correction to: Oncogene (2012) 31, 000–000; doi:10.1038/onc.2012.93; published online 19 March 2012 Since the publication of the above manuscript, the authors have identified an error in the author list; the n...
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Article
Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs
Little is known about metastatic pathways that are specific to the lung rather than other organs. We previously showed that antioxidant proteins such as peroxiredoxins were specifically upregulated in lung met...
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Article
Microsatellite Instability is Associated with the Loss of Apoptosis in Ductal Breast Carcinomas
Metastatic progression in ductal breast carcinomas are related to apoptosis in primary tumors. Frameshift mutations in a single-repeat sequence within the coding region (G)8 of the pro-apoptotic Bax gene have bee...
