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Article
Modeling and in vitro and in vivo characterization of a tissue engineered pancreatic substitute
In designing appropriate devices for the development of a functional pancreatic substitute, computational models capable of accurately predicting cellular behavior constitute a critical aspect. This study inve...
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Chapter
Towards the development of a bioartificial pancreas: immunoisolation and NMR monitoring of mouse insulinomas
A promising method for diabetes treatment is the implantation of immunoisolated cells secreting insulin in response to glucose. Cell availability limits the application of this approach at a medically-relevant...
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Article
Towards the development of a bioartificial pancreas: Immunoisolation and NMR monitoring of mouse insulinomas
A promising method for diabetes treatment is the implantation of immunoisolated cells secreting insulin in response to glucose. Cell availability limits the application of this approach at a medically-relevant...
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Article
Cultivation of recombinant, insulin-secreting AtT-20 cells as free and entrapped spheroids
Animal cells from endocrine glands have potential applications in bioprocessing, for the production of hormones, enzymes, possibly also recombinant proteins, and in tissue engineering, for the development of i...
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Chapter
Use of regulated secretion in protein production from animal cells: An overview
Traditional industrial cell culture processes require extensive downstream product refining due to low product titer and purity in the spent growth medium. A controlled secretion process incorporating cells de...
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Article
Multiple episodes of induced secretion of human growth hormone from recombinant AtT-20 cells
Recombinant AtT-20 cells expressing human growth hormone (hGH) secreted the hormone at a constant, basal rate of 0.3–0.5 ng/105 cells-hour when exposed to medium without secretagogues. When triggered with 8 bromo...
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Article
Peristance of bacteria in the presence of viable, nonencysting, bacterivorous ciliates
Laboratory studies of the interactions between a bacterial population and a population of bacterivorous ciliates consistently show that the bacteria are able to persist in the presence of viable ciliates. Repr...