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Article

Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer

Proteolysis targeting chimeric molecules (Protacs) target proteins for destruction by exploiting the ubiquitin-dependent proteolytic system of eukaryotic cells. We designed two Protacs that contain the peptide...

A Rodriguez-Gonzalez, K Cyrus, M Salcius, K Kim, C M Crews, R J Deshaies… in Oncogene (2008)