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Article
Gold-coated nanoporous polycarbonate track–etched solid platform for the rapid detection of mesothelin
Gold nanolayer—coated polycarbonate track–etched membrane (PCTE)–based microfluidic electrochemical biosensor grown on a highly interactive sandwich-like nanolayer has been designed. The gold nanolayer behaves...
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Article
Sleep disorders in pregnancy and their association with pregnancy outcomes: a prospective observational study
Sleep disturbances such as insomnia, nocturnal awakenings, restless legs syndrome, habitual snoring, and excessive daytime sleepiness are frequent during pregnancy, and these have been linked to adverse matern...
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Article
Testosterone therapy in hypogonadal men and potential prostate cancer risk: a systematic review
This paper provides a systematic review of the literature about prostate cancer risk associated with testosterone therapy for hypogonadism. A comprehensive search of MEDLINE, EMBASE and other resources was con...
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Article
The ‘effectiveness’ scale—therapeutic outcome of pharmacologic therapies for ED: an international consensus panel report
Despite availability of outcome measures and scales for assessing erectile dysfunction (ED) treatment efficacy, guidelines are not available for assessing broader therapeutic outcomes or defining treatment fai...
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Article
Functional prostaglandin E (EP) receptors in human penile corpus cavernosum
In this study, we have characterized functional EP receptors in human corpus cavernosum (HCC) tissue and in HCC smooth muscle cells (SMC). Using RNase protection assays, we determined expression of EP2, EP3I and ...
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Article
Lower extremity above-knee prosthesis-associated erectile dysfunction
Blunt pelvic and perineal trauma has been previously reported to result in site-specific veno-occlusive dysfunction and/or site-specific cavernosal artery insufficiency. We herein describe a case of erectile d...
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Article
Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle
Prostaglandin D2 (PGD2) binds to specific G-protein coupled receptors (DP) and induces smooth muscle relaxation by stimulating the synthesis of intracellular cAMP. In this study, we examined the role of PGD2 and ...
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Article
Pathophysiology of Peyronie's disease
Peyronie's disease is an inflammatory condition characterized by the formation of fibrous, noncompliant nodules in the tunica albuginea which can impede tunical expansion during penile erection, leading to def...
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Article
Rationale for combination therapy of intraurethral prostaglandin E1 and sildenafil in the salvage of erectile dysfunction patients desiring noninvasive therapy
Corpus cavernosum smooth muscle relaxation and hence penile erection are regulated in part by increases in smooth muscle synthesis of the second messengers cyclic adenosine monophosphate (cAMP) and cyclic guan...
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Article
Effect of Hearing Aids on Psychosocial Dysfunctioning
The perception of communication abilities amongest adolescents with moderate and profound hearing loss was correlated with indices of psychosocial adjustment. This was done to determine whether the use of hear...
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Article
Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: urologic and cardiovascular implications
Erectile dysfunction (ED) occurs in varying degrees in an estimated 20 to 30 million American men and is associated with adverse effects on quality of life; particularly personal well-being, family and social...
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Article
Medical and surgical advances in the radical prostatectomy patient
Maintaining the quality of life after surgery in the radical prostatectomy patient is of paramount importance. One of the major dilemmas in surgical management of radical retropubic prostatectomy (RRP) is pres...
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Article
First International Conference on the Management of Erectile Dysfunction Overview consensus statement
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Article
Special Lectures
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Article
Misoprostol induces relaxation of human corpus cavernosum smooth muscle: comparison to prostaglandin E1
Prostaglandin E1 (PGE1) relaxes trabecular smooth muscle by interacting with specific G-protein coupled receptors on human corpus cavernosum smooth muscle and increasing intracellular synthesis of cAMP. Misoprost...
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Article
Preliminary report on the development and characterization of rabbit clitoral smooth muscle cell culture
Purpose: Scientific model systems for physiological evaluation and investigation of pathophysiologies in clitoral function have been limited. The aim was to develop a New Zealand White rabbit clitoral corpus c...
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Article
Engineering analysis of penile hemodynamic and structural-dynamic relationships: Part III—Clinical considerations of penile hemodynamic and rigidity erectile responses
Purpose: The extent to which hemodynamic erectile responses predict penile buckling forces has not previously been analytically investigated. An engineering study was performed to compare hemodynamic data with...
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Article
Engineering analysis of penile hemodynamic and structural-dynamic relationships: Part II—Clinical implications of penile buckling
Purpose: Penile buckling force was analytically described in terms of its constituents. In addition, theoretically-derived buckling force data were compared to clinically measured data and the influence of eac...
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Article
Percutaneous core biopsy of the penis
To describe the efficacy of percutaneous core biopsy of penile corporal tissue, on ten impotent men, the biopsy was performed with a 19 and a 20 gauge core biopsy co-axial system using an automatic biopsy devi...
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Article
Engineering analysis of penile hemodynamic and structural-dynamic relationships: Part I—Clinical implications of penile tissue mechanical properties
Purpose: The least investigated physical determinant of penile rigidity has been penile tissue material properties. The goals in this study (Part I) were to define two penile mechanical parameters, cavernosal ...
