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Article
Open AccessThe new WHO 2022 and ICC proposals for the classification of myelodysplastic neoplasms. Validation based on the Düsseldorf MDS Registry and proposals for a merged classification
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Open AccessAnalysis of the impact of adherence to guidelines and expert advice in patients with myelodysplastic syndromes
The European Leukemia Net (ELN) guidelines for treatment of myelodysplastic syndromes (MDS) connect heterogeneous MDS subgroups with a number of therapeutic options ranging from best supportive care to allogen...
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Article
DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemia
We investigated the prognostic impact of minimal residual disease (MRD) monitoring in acute myeloid leukemia patients harboring DNA methyltransferase 3A-R882H/-R882C mutations (DNMT3Amut). MRD was determined by r...
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Article
Open AccessEpidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO)
We describe genetic and clinical characteristics of acute myeloid leukemia (AML) patients according to age from an academic population-based registry. Adult patients with newly diagnosed AML at 63 centers in G...
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Impact of salvage regimens on response and overall survival in acute myeloid leukemia with induction failure
We evaluated the impact of salvage regimens and allogeneic hematopoietic cell transplantation (allo-HCT) in acute myeloid leukemia (AML) with induction failure. Between 1993 and 2009, 3324 patients with newly ...
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Open AccessCondensed versus standard schedule of high-dose cytarabine consolidation therapy with pegfilgrastim growth factor support in acute myeloid leukemia
The aim of this cohort study was to compare a condensed schedule of consolidation therapy with high-dose cytarabine on days 1, 2 and 3 (HDAC-123) with the HDAC schedule given on days 1, 3 and 5 (HDAC-135) as w...
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Incidence and prognostic impact of ASXL2 mutations in adult acute myeloid leukemia patients with t(8;21)(q22;q22): a study of the German-Austrian AML Study Group
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Erratum: RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features
Correction to: Leukemia advance online publication, 10 June 2016; doi: 10.1038/leu.2016.126 Following the publication of this paper, the authors noted that one of the curves of the Kaplan–Meier plot in Figure ...
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Article
RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features
We evaluated the frequency, genetic architecture, clinico-pathologic features and prognostic impact of RUNX1 mutations in 2439 adult patients with newly-diagnosed acute myeloid leukemia (AML). RUNX1 mutations wer...
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Article
Phase 2 study of oral panobinostat (LBH589) with or without erythropoietin in heavily transfusion-dependent IPSS low or int-1 MDS patients
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Article
Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells
Ineffective hematopoiesis is a major characteristic of myelodysplastic syndromes (MDS) causing relevant morbidity and mortality. Mesenchymal stromal cells (MSC) have been shown to physiologically support hemat...
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Article
Open AccessSequential combination of azacitidine and lenalidomide in del(5q) higher-risk myelodysplastic syndromes or acute myeloid leukemia: a phase I study
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Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): A multicenter study
Myelodysplastic syndromes (MDS) with del(5q) are considered to have a benign course of the disease. In order to address the issue of the propensity of those patients to progress to acute myeloid leukemia (AML)...
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Article
Myelodysplastische Syndrome
Myelodysplastische Syndrome (MDS) sind erworbene Knochenmarkerkrankungen des vornehmlich älteren Menschen, die durch Reifungs- und Funktionsstörungen hämatopoetischer Stammzellen, ineffektive Hämatopoese und e...
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Primary pancreatic lymphoma—a rare cause of cholestasis leading to surgical treatment
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Quantification of outpatient management and hospitalization of patients with high-risk myelodysplastic syndrome treated with low-dose decitabine
Intravenous low-dose 5-aza-2′-deoxycytidine (decitabine) in patients with advanced myelodysplastic syndrome (MDS) yields an approximately 50% overall response rate, including 20–25% complete remission. Decitab...
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Refinement of the international prognostic scoring system (IPSS) by including LDH as an additional prognostic variable to improve risk assessment in patients with primary myelodysplastic syndromes (MDS)
The international prognostic scoring system (IPSS) is considered the gold standard for risk assessment in primary myelodysplastic syndromes (MDS). This score includes several prognostic factors except serum la...
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Article
Art Galleries with Interior Walls
Consider an art gallery formed by a polygon on n vertices with m pairs of vertices joined by interior diagonals, the interior walls. Each interior wall has an arbi- trarily placed, arbitrarily small doorway. W...