31 Result(s)
within
A. Jones
Cancer Research
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Article
Open AccessEstablishing optimal quantitative-polymerase chain reaction assays for routine diagnosis and tracking of minimal residual disease in JAK2-V617F-associated myeloproliferative neoplasms: a joint European LeukemiaNet/MPN&MPNr-EuroNet (COST action BM0902) study
Reliable detection of JAK2-V617F is critical for accurate diagnosis of myeloproliferative neoplasms (MPNs); in addition, sensitive mutation-specific assays can be applied to monitor disease response. However, the...
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Article
Mutations and prognosis in primary myelofibrosis
Patient outcome in primary myelofibrosis (PMF) is significantly influenced by karyotype. We studied 879 PMF patients to determine the individual and combinatorial prognostic relevance of somatic mutations. Ana...
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Article
Open AccessPreoperative ultrasound and FNA in the diagnosis of axillary involvement in invasive breast cancer: correlation with intraoperative one-stop nucleic acid amplification and final histology
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Article
Open AccessElevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients
The role of CHAC1 (cation transport regulator-like protein 1), a recently identified component of the unfolded protein response (UPR) pathway, in gynaecological cancers has not yet been characterised. Now, thi...
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Article
Open AccessThe treatment of early breast cancer in women over the age of 70
One third of all breast cancers are diagnosed in women aged 70 or over. Older women are a heterogeneous population who are under-represented in clinical trials, and as a result uncertainty can exist as to what...
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Article
Genetic analysis of lobular carcinoma in situ and associated invasive lobular cancer
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Article
Open AccessIdiopathic venous thromboembolic disease is associated with a poorer prognosis from subsequent malignancy
We carried out a retrospective study of prognosis in Scottish patients diagnosed with cancer within 5 years after a venous thromboembolism (VTE).
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Article
Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1/CSF1R signaling abnormalities in the cell line GDM1
Imatinib is usually a highly effective treatment for myeloproliferative neoplasms (MPNs) associated with ABL, PDGFRA or PDGFRB gene fusions; however, occasional imatinib-responsive patients have been reported wit...
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Open AccessWaiting times for systemic cancer therapy in the United Kingdom in 2006
This audit was conducted to measure waiting times for systemic cancer therapy across the United Kingdom. All patients, aged 16 years or older, commencing their first course of systemic therapy between 13 Novem...
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Article
JAK2 Mutations are present in all cases of polycythemia vera
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Article
Patient satisfaction with nurse-led telephone consultation for the follow-up of patients with prostate cancer
Prostate cancer is being diagnosed earlier and in higher numbers than ever before. The nature of the disease means many patients have to be monitored regularly and for a prolonged period leading to increased p...
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Article
Open AccessMedical student teaching in the UK: how well are newly qualified doctors prepared for their role caring for patients with cancer in hospital?
A number of studies have identified problems with undergraduate oncology teaching. We have investigated how well prepared newly qualified doctors (first foundation year, or FY1 doctors) are for treating patien...
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Article
Evaluation of oral versus intravenous dose of vinorelbine to achieve equivalent blood exposures in patients with solid tumours
Patient’s preference is for oral chemotherapy when both oral and i.v. are available, provided that efficacy is equivalent. Reliable switch from oral to i.v. is possible if correspondence between respective dos...
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Article
Age has a profound effect on the incidence and significance of chromosome abnormalities in myeloma
A simple high throughput micro-fluorescence in situ hybridisation technique (FISH) was used to detect chromosome 13 deletions (Δ13), immunoglobulin heavy chain (IgH) rearrangements, t(11;14)(q13;q32), t(4;14)(p16...
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Open AccessVinorelbine alternating oral and intravenous plus epirubicin in first-line therapy of metastatic breast cancer: results of a multicentre phase II study
The combination of intravenous (i.v.) vinorelbine and epirubicin is highly active in the treatment of metastatic breast cancer (MBC). In an effort to improve patient convenience, we investigated a regimen alte...
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Article
Open AccessPhase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma
Suramin is an antitrypanosomal agent with antineoplastic activity, but with serious systemic side effects. We administered Suramin intravesically to determine a concentration with low toxicity but with evidenc...
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Article
Open AccessCooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma
Elevated thymidine phosphorylase has been shown to correlate with increased angiogenesis and poor prognosis in many cancers including transitional cell carcinoma of the bladder. In vitro studies have demonstrated...
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Article
Assessment clinics at 'Avon Breast Screening Unit': what has changed in 5 years?
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Article
A Cancer Research (UK) randomized phase II study of idoxifene in patients with locally advanced/metastatic breast cancer resistant to tamoxifen
Idoxifene is a novel selective oestrogen receptor modulator (SERM) which had greater binding affinity for the oestrogen receptor (ER) and reduced agonist activity compared with tamoxifen in preclinical studies...
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Article
Open AccessTrends in postoperative radiotherapy delay and the effect on survival in breast cancer patients treated with conservation surgery
The adequate timing of adjuvant radiotherapy (RT) in breast cancer has become a subject of increasing interest in recent years. A population-based study was undertaken to determine the influence of demographic...
