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Tofacitinib as a novel salvage therapy for refractory T-cell large granular lymphocytic leukemia
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Open AccessPrognostic signature and clonality pattern of recurrently mutated genes in inactive chronic lymphocytic leukemia
An increasing numbers of patients are being diagnosed with asymptomatic early-stage chronic lymphocytic leukemia (CLL), with no treatment indication at baseline. We applied a high-throughput deep-targeted anal...
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Article
Open AccessThe relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes
Nonsynonymous TP53 exon 4 single-nucleotide polymorphism (SNP), R72P, is linked to cancer and mutagen susceptibility. R72P associations with specific cancer risk, particularly hematological malignancies, have bee...
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Recurrent genetic defects on chromosome 7q in myeloid neoplasms
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Open AccessNovel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation
T-cell large granular lymphocytic (T-LGL) leukemia is a clonal disease characterized by the expansion of mature CD3+CD8+ cytotoxic T cells. It is often associated with autoimmune disorders and immune-mediated ...
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Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies
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SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts
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Measuring the prognostic impact of ferritin levels in myelodysplastic syndrome patients: the role of susceptibility biases