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Gender disparity in the journal hernia and its affiliated societies
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Open AccessReducing short-acting beta-agonist use in asthma: Impact of national incentives on prescribing practices in England and the findings from SENTINEL Plus early adopter sites
Short-acting beta-agonist (SABA) over-use in asthma is harmful for patients and the environment. The Investment and Impact Fund (IIF) 2022/2023 financially rewarded English primary care networks that achieved ...
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Natural history of occult hernias in adults at a safety-net hospital
Occult hernias, hernias seen on radiologic imaging but not felt on physical exam, are common. Despite their high prevalence, little is known about the natural history of this finding. Our aim was to determine ...
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Article
Closed-loop optogenetic control of the dynamics of neural activity in non-human primates
Electrical neurostimulation is effective in the treatment of neurological disorders, but associated recording artefacts generally limit its applications to open-loop stimuli. Real-time and continuous closed-lo...
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Inhibition of Micro-pitting by Tribofilm-Forming ZrO2 Nanocrystal Lubricant Additives: A Micro-pitting Rig and Transmission Electron Microscope Study
The drive to reduce fuel consumption in transportation has encouraged the emergence of low viscosity lubricants to reduce viscous losses in the engine, drivetrain, and other components. However, viscosity redu...
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Open AccessClinical characteristics and outcome of critically ill COVID-19 patients with acute kidney injury: a single centre cohort study
Acute kidney injury (AKI) is a common manifestation among patients critically ill with SARS-CoV-2 infection (Coronavirus 2019) and is associated with significant morbidity and mortality. The pathophysiology of...
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Prevalence of HIV Viral Load Suppression Among Psychiatric Inpatients with Comorbid Substance Use Disorders
A consistently suppressed viral load enables HIV (+) patients to live longer, healthier lives and reduces the probability of transmitting the virus. Since the prevalence of HIV is four times higher among those...
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Open AccessRepeatability of quantitative 18F-FLT uptake measurements in solid tumors: an individual patient data multi-center meta-analysis
3′-deoxy-3′-[18F]fluorothymidine (18F–FLT) positron emission tomography (PET) provides a non-invasive method to assess cellular proliferation and response to antitumor therapy. Quantitative 18F–FLT uptake metrics...
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Open AccessImplementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives
For body imaging, diffusion-weighted MRI may be used for tumour detection, staging, prognostic information, assessing response and follow-up. Disease detection and staging involve qualitative, subjective asses...
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N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice
N-acetylcysteine can increase extrasynaptic glutamate and reduce nicotine self-administration in rats and smoking rates in humans.
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Open AccessOxygen-enhanced MRI can accurately identify, quantify and map tumour hypoxia in preclinical models
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Open Access0920. Cerebrovascular autoregulation in normotensive hypovolaemia: a study combining lower body negative pressure and MRI
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Open Access0918. Grey matter perfusion is preserved during normotensive hypovolaemia, despite reductions in total cerebral blood flow: evidence of local, pressure independent, intra-cerebral vascular autoregulatory response
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Effect of varenicline on aspects of inhibitory control in smokers
Varenicline, a partial agonist at α4β2 nicotinic receptors (nAChRs) aids smoking cessation by reducing craving. Successful quitting may be associated with greater inhibitory control but the effectiveness of va...
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Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo
In vivo delivery is a major barrier to the use of molecular tools for gene modification. Here we demonstrate site-specific gene editing of human cells in vivo in hematopoietic stem cell-engrafted NOD.Cg-Prkdcscid
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Open AccessImmune response after vaccination of HIV infected individuals receiving HAART with overlap** gag peptides pulsed on autologous cells
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Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging
Many therapeutic approaches to cancer affect the tumour vasculature, either indirectly or as a direct target. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has become an important means of inv...
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Genetic variation and association map** of silica concentration in rice hulls using a germplasm collection
An association analysis on the genetic variability for silica concentration in rice hulls was performed using a “Mini-Core” set of 174 accessions representative of the germplasm diversity found in the USDA wor...
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Effect of Serotherapy dose on Immunoreconstitution Following Umbilical Cord Stem Cell Transplant for Primary Immunodeficiency
Background: Severe Primary Immunodeficiencies (PID) have high morbidity and mortality. Umbilical cord blood stem cell transplantation (UCSCT) is curative. Conditioning regimens aid engraftment and long-term thymo...
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A two-part Phase II study of cediranib in patients with advanced solid tumours: the effect of food on single-dose pharmacokinetics and an evaluation of safety, efficacy and imaging pharmacodynamics
Cediranib (RECENTIN™) is an oral, highly potent VEGF inhibitor. This study evaluated the effect of food on the pharmacokinetics of cediranib and compared the administration of continual cediranib via two dosin...
