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Article
Open AccessRegional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England
Laparoscopic and now robotic colorectal surgery has rapidly increased in prevalence; however, little is known about how uptake varies by region and sociodemographics. The aim of this study was to quantify the ...
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Article
Open AccessCharacteristic patterns of EEG oscillations in sheep (Ovis aries) induced by ketamine may explain the psychotropic effects seen in humans
Ketamine is a valuable anaesthetic and analgesic that in recent years has gained notoriety as a recreational drug. Recently, ketamine has also been proposed as a novel treatment for depression and post-traumat...
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Article
Open AccessAntagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington’s disease
Antagonist pleiotropy, where a gene exerts a beneficial effect at early stages and a deleterious effect later on in an animal’s life, may explain the evolutionary persistence of devastating genetic diseases su...
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Protocol
Erratum to: Large-Brained Animal Models of Huntington’s Disease: Sheep
The name of the Chapter 12 author had been inadvertently mentioned as “Jennifer Morton A”. This has been correctly updated as “Morton. A. J”.
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Protocol
Large-Brained Animal Models of Huntington’s Disease: Sheep
The limitations of using small-brained rodents to model diseases that affect large-brain humans are becoming increasingly obvious as novel therapies emerge. Huntington’s disease (HD) is one such disease. In re...
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Article
Pharmacokinetics and immunological outcomes of alemtuzumab-based treatment for steroid-refractory acute GvHD
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Article
Precipitation in a Ag-Containing Mg-Y-Zn Alloy
The precipitation in a Mg-6Y-2Ag-1Zn-0.6Zr (wt pct) alloy during isothermal aging at and above 473 K (200 °C) has been examined systematically using conventional transmission electron microscopy, high-angle an...
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Article
Understanding the concept of a reflective surface: Can sheep improve navigational ability through the use of a mirror?
Mirror image-induced stimulation and the ability to use the mirror to improve navigational ability for the purpose of object location are considered measures of animal cognitive ability. The purpose of this st...
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Article
On the Structure, Transformation and Deformation of Long-Period Stacking Ordered Phases in Mg-Y-Zn Alloys
Ternary Mg-Y-Zn alloys have attracted considerable attention due to their unique microstructures and promising mechanical properties. The microstructure of these alloys contains predominantly intermetallic pha...
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Article
Hand tap**: A simple, reproducible, objective marker of motor dysfunction in Huntington’s disease
Huntington’s disease (HD) is a severe neurodegenerative condition in which the impairment in voluntary movement is related to functional disability. Clinical assessment of motor deficit currently relies largel...
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Article
Open AccessThe quantification of habitat architecture for explanations of arthropod assemblage patterns: a comparison of two methods
A drop disc, originally conceived as a quick and easy method of measuring vegetation height, was compared to the more labour-intensive point quadrat pins in terms of usefulness in quantifying the vertical arch...
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Article
Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation
The significance of neuronal intranuclear inclusions (NIIs) and extranuclear inclusions (ENNIs) in the brains of patients with polyglutamine repeat diseases and transgenic mice modelling these diseases is hotl...
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Article
Effects of ozone on calcareous grassland communities
A system of 16 open-top chambers was used to investigate the effects of a range of ozone concentrations typical of those found in southern Britain on the species composition of calcareous grassland communities...
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Article
The morphology of human neuroblastoma cell grafts in the kainic acid-lesioned basal ganglia of the rat
Cells from a human neuroblastoma cell line (SH-SY5Y) have been used to examine their potential suitability as donor cells for neural transplantation. Grafts of SH-SY5Y cells were placed in the basal ganglia of...
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Article
Structure/Property Relationships in a Rapidly Solidified and Annealed Ternary Iron Aluminide
Rapidly solidified strips of Fe66.5-Al28.5-Cr5 alloy with the addition of 0.5wt.% TiB2, were produced by planar flow strip casting. Correlations of the microstructure and room temperature mechanical properties we...
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Article
Electron diffuse scattering studies of premartensitic alloys: β' Cu-Zn, β' Ni-Al, In-TI, and Fe-Ni
Electron diffuse scattering patterns obtained from β' Cu-Zn, β' Ni-Al, In-TI, and Fe-Ni alloys in their premartensitic conditions have been analyzed and compared with Kohn constructions which map Fermi surface...
