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Article
Open AccessNOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice
The interleukin-1 family members, IL-1β and IL-18, are processed into their biologically active forms by multi-protein complexes, known as inflammasomes. Although the inflammasome pathways that mediate IL-1β p...
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Article
Open AccessTrends in thyroid function testing, neck ultrasound, thyroid fine needle aspiration, and thyroidectomies in North-eastern Italy
Evidence of an increased diagnostic pressure on thyroid has emerged over the past decades. This study aimed to provide estimates of a wide spectrum of surveillance indicators for thyroid dysfunctions and disea...
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Article
Rectal sparing approach after preoperative radio- and/or chemotherapy (RESARCH) in patients with rectal cancer: a multicentre observational study
Rectum-sparing approaches appear to be appropriate in rectal cancer patients with a major (mCR) or complete clinical response (cCR) after neoadjuvant therapy. The aim of the present study is to evaluate the e...
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Article
Open AccessAn immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts
Despite some success with certain hematological malignancies and in contrast with the strong pro-apoptotic effects measured in vitro, the overall response rate of acute lymphoblastic leukemia (ALL) to histone dea...
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Article
New Solution of Diffusion–Advection Equation for Cosmic-Ray Transport Using Ultradistributions
In this paper we exactly solve the diffusion–advection equation (DAE) for cosmic-ray transport. For such a purpose we use the Theory of Ultradistributions of J. Sebastiao e Silva, to give a general solution fo...
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Article
Open AccessPrognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab
AMP-activated protein kinase (AMPK) has a central role in cellular energy sensing and is activated in preclinical tumour models following anti-vascular endothelial growth factor (VEGF) therapy. The possible pr...
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Article
Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy
The aim of the study was the identification of a pharmacogenetic profile predictive of the tumor regression grade (TRG), considered as tumor response parameter, after neo-adjuvant treatment in rectal cancer pa...
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Article
Open AccessRisk of death among Italian AIDS cases with AIDS-defining cancers in the post-HAART era
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Article
40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Article
Open AccessLong-term survival of stage I multiple myeloma given chemotherapy just after diagnosis or at progression of the disease: a multicentre randomized study
We conducted a randomized trial to evaluate whether melphalan-prednisone (MPH-P) treatment administered just after diagnosis improves survival of stage I multiple myeloma (MM). Between January 1987 and March 1...
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Chapter and Conference Paper
Der Laser — ein flexibles Werkzeug im Fertigungseinsatz. Praxiserfahrung und Ausblick
Der globale Wettbewerb, dem produzierende Unternehmen ausgesetzt sind, erfordert die ständige Entwicklung funktional verbesserter Erzeugnisse sowie die Weiterentwicklung der für ihre wirtschaftliche Fertigung ...
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Article
Relevance of age on survival of 341 patients with multiple myeloma treated with conventional chemotherapy: updated results of the MM87 prospective randomized protocol
Age could influence the prognosis of multiple myeloma patients treated with conventional chemotherapy. Between January 1987 and March 1990, 341 consecutive previously untreated patients with multiple myeloma r...
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Article
Experience with poorly myelosuppressive chemotherapy schedules for advanced myeloma
In a multicentre study, 83 patients with advanced and previously uniformly treated multiple myeloma (MM) were randomised between cyclophosphamide (600 mg m-2) and epirubicin (70 mg m-2), administered every 3 w...
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Article
Treatment of multiple myeloma according to the extension of the disease: a prospective, randomised study comparing a less with a more aggressive cytostatic policy
The purpose of the study was to ascertain whether the prognostic significance of staging in multiple myeloma (MM) is influenced by the aggressiveness of effective induction treatment and/or by continuing or di...
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Chapter and Conference Paper
p53 expression in human soft tissue sarcomas. Correlation with biological aggressiveness
The p53 gene located at chromosome 17 p13 encodes a MW 53,000 nuclear phosphoprotein which is frequently mutated in many human cancers [1]. The mutant p53 protein has a much longer half-life than the wild-type...
