10 Result(s)

Article

Response to: Letter to Editor Regarding “Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study”

A. David Burden in Dermatology and Therapy (2024)

Article

Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study

We evaluated the anti-interleukin-36 receptor antibody spesolimab in patients with moderate-to-severe palmoplantar pustulosis (PPP).

A. David Burden, Robert Bissonnette, Alexander A. Navarini… in Dermatology and Therapy (2023)

Article

Design of Effisayil™ 2: A Randomized, Double-Blind, Placebo-Controlled Study of Spesolimab in Preventing Flares in Patients with Generalized Pustular Psoriasis

Generalized pustular psoriasis (GPP) is a rare autoinflammatory skin disease characterized by flares of widespread erythema with sterile pustules, and can be relapsing with recurrent flares, or persistent with...

Akimichi Morita, Siew Eng Choon, Hervé Bachelez… in Dermatology and Therapy (2023)

Article

Symptom Experience and Content Validity of the Psoriasis Symptom Scale (PSS) in Patients with Generalized Pustular Psoriasis (GPP)

We sought to understand key symptoms of generalized pustular psoriasis (GPP) and to confirm the relevance to patients and content validity of the Psoriasis Symptom Scale (PSS) in GPP.

A. David Burden, Ulrich Mrowietz, Anne M. Skalicky… in Dermatology and Therapy (2022)

Article

Clinical Disease Measures in Generalized Pustular Psoriasis

Generalized pustular psoriasis (GPP) is a rare neutrophilic skin condition characterized by episodes of widespread eruption of sterile macroscopic pustules that can be associated with systemic inflammation. Th...

A. David Burden, Siew Eng Choon… in American Journal of Clinical Dermatology (2022)

Article

The BSR-PsA: study protocol for the British Society for Rheumatology psoriatic arthritis register

Psoriatic arthritis (PsA) presents a unique clinical challenge. Affecting joints, skin, nails, and other organs, it is associated with various comorbidities and has a significant impact on quality of life, soc...

Gareth T. Jones, Gary J. Macfarlane, Karen Forrest Keenan, Paul McNamee… in BMC Rheumatology (2021)

Article

Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study

Palmoplantar pustulosis (PPP) is a chronic, inflammatory skin disease, with high disease burden, that is often refractory to treatment. There is a high unmet clinical need for the treatment of patients with P...

Ulrich Mrowietz, A. David Burden, Andreas Pinter, Kristian Reich… in Dermatology and Therapy (2021)

Article

Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne

Acne vulgaris is a highly heritable common, chronic inflammatory disease of the skin for which five genetic risk loci have so far been identified. Here, we perform a genome-wide association study of 3823 cases...

Christos Petridis, Alexander A. Navarini, Nick Dand… in Nature Communications (2018)