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Article
Growth, body composition and hormonal axes in children and adolescents
Growth and physical maturation are dynamic processes that encompass a broad range of cellular and somatic changes. Most investigators who study growth have focused on linear growth (change in height over time)...
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Article
Consequences of sport training during puberty
Growth at puberty depends on one’s genetic potential, nutritional status and a series of hormones. Energy expenditure may modify the effects of these three factors on the linear growth rate and the relative pr...
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Chapter and Conference Paper
Regulatory Actions of Testosterone on Pulsatile Growth Hormone Secretion in the Human: Studies Using Deconvolution Analysis
Sex steroid hormones profoundly influence multiple endocrine axes, including not only the gonadotropic but also the growth hormone (GH) axis (1). In the rat intact male and female animals exhibit strikingly diffe...
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Article
QUANTITATION OF CORTISOL (F) PRODUCTION AND ELIMINATION RATES IN PREMATURE AND TERM NEONATES: EVIDENCE FOR PULSATILE SECRETION
Pulsatile secretion of cortisol has not been documented in the newborn infant. Using repeated blood sampling and deconvolution analysis, we investigated F secretory and elimination dynamics in a clinically sta...
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Article
A LONGITUDINAL ASSESSMENT OF IGFBP-3 CONCENTRATION IN NORMAL BOYS
Recent data indicate the serum concentration of IGFBP-3 (the major post-natal IGF binding protein) may be clinically important in some pathophysiologic states. Existing cross-sectional data suggest an ontogeny...
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Chapter and Conference Paper
Effects of Gonadal Steroid Hormones on Growth and Growth Hormone Secretion at Puberty in Humans
Growth in children is a dynamic process that occurs due to the continuing interaction of the genetic constitution and nutrition, as modified (modulated) by hormonal secretion and clearance. During early childh...
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Article
Effects of opioid receptor blockade on luteinizing hormone (LH) pulses and interpuise LH concentrations in normal women during the early phase of the menstrual cycle
To determine the role of endogenous opioid peptides in regulating pulsatile luteinizing hormone (LH) release in the early follicular phase of the menstrual cycle of eumenorrheic women, we evaluated serum LH co...
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Chapter
Patterns of Growth Hormone Release During Childhood and Adolescent Development in the Human
Growth hormone (GH) is released in an episodic, burst-like (pulsatile) manner throughout the day, but especially following the onset of slow-wave sleep (stages 3 and 4). Its secretion is controlled by two hypo...
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Chapter
Therapeutic Effects of Growth Hormone Releasing Hormone
The existence of hypothalamic-hypophyseal releasing factors was suggested by the pioneering work of Sir Geoffrey Harris (1); Reichlin and co-workers postulated that a specific releasing factor for growth hormo...
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Chapter
Age and Sex-Related Neurosecretion of Growth Hormone
Although it has long been recognized that the secretion of growth hormone (GH) is influenced by age and sex, the mechanisms through which these factors mediate their effects remain incompletely understood. Ind...
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Article
Actions of calcium ions and a calcium-influx blocker on basal and TRH- and GnRH-stimulated hormone release in patients with pituitary adenomas
We investigated the influence of calcium ions on the secretion of anterior pituitary hormones basally and in response to exogenous hypothalamic releasing factors in 6 men with pituitary tumors. To this end, co...
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Article
Human pancreatic tumor GH-releasing factor
Within the past year, three similar peptides with specific growth hormone (GH) releasing effects have been extracted from human tissue, identified, and synthesized. Human pancreatic tumor GH releasing factor (...
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Article
GROWTH HORMONE (GH) RELEASE IN CHILDREN WITH SHORT STATURE: STIMULATION BY HUMAN PANCREATIC TUMOR GROWH HORMONE RELEASING FACTOR-40 (hpGRF-40)
44 short children were evaluated for GH reserve after pharmacologic tests and a single IV injection of hpGRF-40. Four groups were studied 1) Idiopathic GH deficiency (IGHD) 2) Organic hypopituitarism 3) Intrau...
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Article
INSULIN BINDING TO THE HL-60 HUMAN PROMYELOCYTIC CELL LINE
The HL-60 cell line derived from a patient with promyelocytic leukemia may be grown in liquid suspension cell culture. It binds [125I]-iodoinsulin in a highly specific, rapid, reversible, temperature and pH depen...
