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Article
The Effects of the Low Molecular Weight Nerve Growth Factor Mimetic GK-2 on Cognitive Function and Synaptic Transmission in Hippocampal Slices
Abstract—Nerve growth factor (NGF) contributes to the proliferation, differentiation, and maintenance of the viability and functioning of peripheral and central neurons. At the Zakusov Research Institute of Pharm...
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Article
Effect of Chronic Administration of Obestatin and Its Fragment FNAP-NH2 on Behavioral Activity and Nociceptive Threshold in Rats with Normal and Excess Body Weight
The effects of chronic intranasal administration of 300 nmol/kg obestatin and its fragment FNAP-NH2 on behavioral activity and nociceptive threshold were examined in male Wistar rats with normal body weight or al...
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Article
Paradoxical influence of combined effect of Semax and ammonium molybdate on learning and memory in rats
The combined effect of Semax with water solutions of plumbum diacetate (10–7 M) and ammonium molybdate (10–5 M) on the two-way active avoidance learning in rats in the shuttle chamber was studied. It was establis...
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Article
Changes in Behavior and Blood Corticosterone Level in Male and Female Rats after Single Administration of Obestatin Fragment 1-4
Single administration of the obestatin fragment 1-4 (300 nmol/kg) to male Wistar rats produced a significant weight loss in male rats on observation days 5-8, while in female rats only on day 8. In addition, m...
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Article
Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats
We studied the effects of anorectic peptide obestatin and its fragment (1-4) on the antioxidant defense system in animals with normal and experimentally induced increased body weight. In rats with normal body ...
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Article
Differently Directed Influences of Semax on the Formation and Functional Impairments of an Active Avoidance Reaction in Rats
The effects of Semax on the formation of a conditioned active avoidance reaction were studied in rats using different experimental models. I.p. administration of Semax at a dose of 0.05 mg/kg was found to acce...
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Article
Changes in feeding and drinking motivations and glucose content in male rats after single or chronic administration of obestatin or its fragment (1–4)
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Article
Effects of single intranasal administration of obestatin fragments on the body weight and feeding and drinking behaviors
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Article
Optimization of Choline Administration Regimen for Correction of Cognitive Functions in Rats after Brain Injury
Choline diet promotes improvement of the brain cognitive functions in rats with moderateto-severe traumatic brain injury. In previous studies, the rats received choline being standart (0.2%) or choline-supplem...
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Article
Effect of Anorexigenic Peptide Obestatin on Platelet Aggregation and Osmotic Resistance of Erythrocytes
We studied the effects of the anorexigenic peptide obestatin on the coagulation system and blood rheology (by the parameters of platelet aggregation and osmotic resistance of erythrocytes) in vitro and in vivo. O...
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Article
The effects of new nociceptin analogs on the behavior of white rats
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Article
Semax prevents functional impairments of avoidance response in rats
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Article
Studies of the Delayed Effects of Acute Prenatal Stress Evoked by Forced Swimming
The aim of the present work was to evaluate the delayed effects of acute prenatal stress in white rats. Stress was imposed by forced swimming in cold water on days 7 or 14 of pregnancy. The results showed that...
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Article
The Nootropic and Analgesic Effects of Semax Given via Different Routes
The heptapeptide Semax (MEHFPGP) is an analog of the fragment ACTH(4–10) with long-lasting actions. The aim of the present work was to study the effects of Semax on learning ability and pain sensitivity in whi...
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Article
Effects of acute and chronic administration of exorphin C on behavior and learning in white rat pups
We studied the behavior of 21- and 35-day-old white rat pups in the “open field” and the learning of 36- to 41-day-old pups in a maze with food reinforcement. An opioid fragment of wheat gluten exorphin C (YPI...
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Article
Delayed effect of exorphins on learning of albino rat pups
The delayed effect of food-derived opioid peptides (exorphins) after chronic administration on postnatal days 1–14 on the learning of albino rat pups has been studied. Heptapeptide YPFPGPI (β-casomorphin-7), p...
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Article
Exploratory activity of mice of different genetic strains after olfaction disruption by 3-methylindole (skatole)
The behavior of mice of two inbred strains (C57BL/6J and CBA) and their F1 hybrids was evaluated in the open field test after intraperitoneal administration of 3-methylindole (skatole) disrupting epithelium of...
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Article
Exploratory behavior and anxiety level of white outbred rats after blocking olfaction with N-trimethylindole (skatole)
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Article
Effect of β-casomorphines on mother-oriented (“Child’s”) behavior of white rats
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Article
Orientation and exploratory behavior and anxiety of CBA mice with anosmia induced by N-trimethylindole (skatole)
The behavior of CBA mice in the hole-board test and elevated plus maze was studied after intraperitoneal injection of skatole leading to destruction of the epithelium in the main olfactory system. Locomotor an...
