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  1. No Access

    Article

    Synthesis of novel thiourethane analogs of neurolipins

    Thiourethane analogs of anandamide and arachidonic acid amides with cyclopropylamine, dopamine, and serotonin that were capable of inhibiting hydrolysis of fatty-acid amides and interacting with cannabinoid re...

    N. M. Gretskaya, A. A. Druzhinina, M. Yu. Bobrov… in Chemistry of Natural Compounds (2013)

  2. No Access

    Article

    Synthesis and bacteriostatic activity of 2-dialkylaminomethyl-4,5,6,7-tetrahalogenoindoles

    A. N. Grinev, A. A. Druzhinina, I. K. Sorokina… in Pharmaceutical Chemistry Journal (1979)

  3. No Access

    Article

    Synthesis and chemotherapeutic study of polyhalogen derivatives of indole

    A. N. Grinev, A. A. Druzhinina, I. K. Sorokina… in Pharmaceutical Chemistry Journal (1977)

  4. No Access

    Article

    Research in the imidazole series

    The reduction of pyrrolo[1,2-a]imidazole-2-one and pyrrolo[1,2-a]benzimidazole derivatives, which leads to the formation of 2,3-dihydropyrrolo[1,2-a]imidazole derivatives and derivatives of the previously unkn...

    A. A. Druzhinina, P. M. Kochergin, R. M. Palei… in Chemistry of Heterocyclic Compounds (1977)

  5. No Access

    Article

    Research in the imidazole series

    The hydrolysis of 7-cyano derivatives of pyrrolo[1,2-a]imidazole in 85–90% sulfuric acid at 100°C gives amides of pyrroloimidazole-7-carboxylic acids. Under more severe conditions, the resulting carboxylic aci...

    A. A. Druzhinina, P. M. Kochergin in Chemistry of Heterocyclic Compounds (1976)

  6. No Access

    Article

    Research in the imidazole series

    The Mannich reaction in the 6-aryl-7-cyanopyrrolo[1,2-a] imidazole series was studied, and the corresponding 5-dialkylaminomethyl derivatives of this heterocycle were obtained.

    A. A. Druzhinina, P. M. Kochergin in Chemistry of Heterocyclic Compounds (1976)

  7. No Access

    Article

    Research in the imidazole series

    The reaction of 1-alkyl-2-cyano (alkoxycarbonyl)methyl derivatives of imidazole and benzimidazole with α-halo ketones was studied. It was established that the presence of electron-acceptor substituents (CN, COOC2

    P. M. Kochergin, A. A. Druzhinina, R. M. Palei in Chemistry of Heterocyclic Compounds (1976)

  8. No Access

    Article

    New pyrazino[1,2-a]benzimidazole derivatives

    1-Ethoxycarbonyl-3-phenyl- and 3-phenylpyrazino[1,2-a]benzimidazoles were synthesized by reaction of 2-ethoxalyl- and 2-diethoxymethyl-N-phenacylbenzimidazoles, obtained from the corresponding sodium derivativ...

    A. N. Grinev, A. A. Druzhinina, I. K. Sorokina in Chemistry of Heterocyclic Compounds (1976)

  9. No Access

    Article

    Synthesis and antiserotonin activity of pyrrolo[1,2-a]imidazole derivatives

    P. M. Kochergin, M. D. Mashkovskii, A. A. Druzhinina… in Pharmaceutical Chemistry Journal (1976)

  10. No Access

    Article

    Relative stabilities of the tautomeric forms of conjugate acids and kinetics of deuterium exchange in derivatives of indolizine, pyrrolo [1,2-a] imidazole, and pyrrolo [1,2-a]benzimidazole

    The effect of the temperature and the acidicity of the medium on the ratio of the two tautomeric forms of the conjugate acids of derivatives of indolizine, pyrrolo[1,2-a]imidazole, and pyrrolo[1,2-a]benzimidaz...

    L. M. Alekseeva, G. G. Dvoryantseva, Yu. N. Sheinker… in Chemistry of Heterocyclic Compounds (1976)

  11. No Access

    Article

    Protonation of pyrrolo[1,2-a] imidazole derivatives

    The protonation of a number of pyrrolo[1,2-a]imidazole derivatives in trifluoroacetic acid was studied by PMR spectroscopy. The 5,7-unsubstituted compounds form a mixture of two forms of cations, the structures o...

    L. M. Alekseeva, G. G. Dvoryantseva… in Chemistry of Heterocyclic Compounds (1972)

  12. No Access

    Article

    Investigations in the imidazole series LXXIV. Electrophilic substitution reactions in the pyrrolo[1,2-a]imidazole series

    The formylation, acetylation, hydroxymethylation, azo coupling, nitrosation, nitration, and chloromercuration of pyrrolo[1,2-a]imidazole derivatives were studied. The PMR spectra were used to establish that al...

    A. A. Druzhinina, P. M. Kochergin, L. M. Alekseeva in Chemistry of Heterocyclic Compounds (1972)

  13. No Access

    Article

    Studies in the imidazole series

    The debenzylation of N-benzyl-substituted 1H-pyrrolo[1,2-a]imidazoles and 4H-pyrrolo-[1,2-a]benzimidazoles under the influence of sodium in liquid ammonia was studied. From the IR and PMR spectra it was establish...

    P. M. Kochergin, Yu. N. Sheinker, A. A. Druzhinina… in Chemistry of Heterocyclic Compounds (1971)

  14. No Access

    Article

    Investigations in the imidazole series

    The synthesis of derivatives of 2,3-dihydropyrrolo[1,2-a]imidazole from 1,2-dialkylimidazolines or 1,2-diarylkylimidazolines and phenacyl bromides with subsequent heating of the 1,2-disubstituted 3-phenacyl-im...

    A. A. Druzhinina, P. M. Kochergin in Chemistry of Heterocyclic Compounds (1969)

  15. No Access

    Article

    Studies in the imidazole series

    By quaternization of 1-alkyl(aryl, aralkyl)-2-methyl-4, 5-diarylimidazoles with α-bromo ketones and by subsequent cyclization of the quaternary salts of imidazole, a number of arylpyrrolo[1,2-a]imida~ zoles we...

    A. A. Druzhinina, P. M. Kochergin, N. P. Bychkova in Chemistry of Heterocyclic Compounds (1969)

  16. No Access

    Article

    Researches on imidazoles

    Reaction of 1,2-dialkylimidazoles withα-halogenoketones gives a number of 1,2-dialkyl-3-[ß-ketoalkyl(aialkyl)] imidazolinium halides. A study is made of the products of reaction of some imidazolinium halides with...

    A. A. Druzhinina, P. M. Kochergin in Chemistry of Heterocyclic Compounds (1967)

  17. No Access

    Article

    Researches on imidazoles

    A number of pyrrol[1,2-a]imidazole derivatives are synthesized by heating 1,2-dialkyl-3-[β-ketoalkyl(aralkyl)]imidazolinium halides with aqueous sodium bicarbonate, or by heating the corresponding imidazoliniu...

    A. A. Druzhinina, P. M. Kochergin in Chemistry of Heterocyclic Compounds (1967)

  18. No Access

    Article

    Synthesis of pyrrolo [1,2-a] imidazole and pyrrolo [1,2-a] benzimidazole derivatives

    P. M. Kochergin, A. A. Druzhinina, R. M. Palei in Chemistry of Heterocyclic Compounds (1966)