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Article
Multi-rotor wake characterization and visualization in ascending and descending flight
This study employs wind tunnel experiments to investigate the wake characteristics of multi-rotor unmanned air vehicles in ascending and descending vertical flight modes. First, flow visualization is used to o...
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Chapter and Conference Paper
Impacts of Test Fixture Connections of the BARC Structure on Its Dynamical Responses
The Box Assembly with Removable Component (BARC) structure has been recently introduced as a challenge problem for the study of the effects of boundary conditions on vibrational testing and modal analysis. Cur...
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Chapter and Conference Paper
Experimental and Computational Investigations on Fixture Interference for BARC Systems
For most dynamical systems, there is much uncertainty for boundary conditions between experiments, simulations, and service environments. The Box Assembly with Removable Component attempts to investigate these...
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Article
Open AccessFrequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia
Although tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of chronic myeloid leukemia (CML), the ability of TKIs to eradicate CML remains uncertain and patients must continue TKI the...
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Article
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients
To clarify the cooperative roles of recurrently identified mutations and to establish a more precise risk classification system in acute myeloid leukemia (AML), we comprehensively analyzed mutations in 51 gene...
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Article
Nella malattia di Cushing da macroadenoma invasivo la bassa espressione della O(6)-metilguanina-DNA-metiltransferasi è frequente
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Article
Erratum: CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells
Correction to: Leukemia (2009) 23, 1329–1336; doi:10.1038/leukemia.2009.77; published online 16 April 2009 Since the publication of this paper, the authors have noticed an error in Figure 1. The correct figure...
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Article
CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells
We studied the effect of CMC-544, the calicheamicin-conjugated anti-CD22 monoclonal antibody, used alone and in combination with rituximab, analyzing the quantitative alteration of target molecules, that is, C...
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Article
ZD6474 induces growth arrest and apoptosis of human leukemia cells, which is enhanced by concomitant use of a novel MEK inhibitor, AZD6244
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Article
Efficacy of gemtuzumab ozogamicin on ATRA- and arsenic-resistant acute promyelocytic leukemia (APL) cells
Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is a target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). In this study, we exami...
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Article
Antimonocyte chemoattractant protein-1 gene therapy reduces experimental in-stent restenosis in hypercholesterolemic rabbits and monkeys
In-stent restenosis results exclusively from neointimal hyperplasia due to mechanical injury and a foreign body response to the prosthesis. Inflammation mediated by monocyte chemoattractant protein-1 (MCP-1) m...
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Article
Impairment of heart rate variability control during arsenic trioxide treatment for acute promyelocytic leukemia
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Article
Inhibition of neointimal hyperplasia after balloon injury by cis-element ‘decoy’ of early growth response gene-1 in hypercholesterolemic rabbits
Early growth response factor-1 (Egr-1) is a transcription factor that is rapidly activated after vascular injury and thus might contribute to vascular proliferation and inflammation. We hypothesized that Egr-1...
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Article
P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are induced by arsenic trioxide (As2O3), but are not the main mechanism of As2O3-resistance in acute promyelocytic leukemia cells
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Article
Serum lipid profiles in Japanese women and men during consumption of walnuts
Objective: To determine the serum cholesterol, apolipoproteins and LDL oxidizability in young Japanese women and men during walnut consumption and to evaluate its active principle.
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Article
Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug resistance modifiers
Gemtuzumab ozogamicin (CMA-676), a calicheamicin-conjugated humanized anti-CD33 mouse monoclonal antibody, has recently been introduced clinically as a promising drug for the treatment of patients with acute m...
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Article
Arsenic trioxide therapy for relapsed or refractory Japanese patients with acute promyelocytic leukemia: need for careful electrocardiogram monitoring
Recent studies have shown that arsenic trioxide (As2O3) can induce complete remission in patients with acute promyelocytic leukemia (APL). We tested the efficacy and safety of As2O3 for the treatment of patients ...
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Article
Obesity, body fat distribution and coronary atherosclerosis among Japanese men and women
OBJECTIVE: To investigate the relation of the obesity and body-fat distribution with angiographically defined coronary atherosclerosis.
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Article
In vitro IL-12 treatment of peripheral blood mononuclear cells from patients with leukemia or myelodysplastic syndromes: increase in cytotoxicity and reduction in WT1 gene expression
Interleukin-12 (IL-12) has potent antitumor activities. We examined whether IL-12 enhanced the cytotoxicity of peripheral blood mononuclear cells (PBMNC) and decreased leukemia cells in 30 patients with leukem...
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Article
Increased sensitivity of multidrug-resistant myeloid leukemia cell lines to lovastatin
Lovastatin, a competitive inhibitor of HMG-CoA reductase, reportedly inhibits proliferation and induces apoptosis of tumor cells with MDR-1 coded P-glycoprotein (Pgp) expression. In this study we investigated ...
