31 Result(s)
within
A Smith
Molecular Medicine
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Article
Open AccessEvaluating the risk of ovarian cancer before surgery using the ADNEX model: a multicentre external validation study
The International Ovarian Tumour Analysis (IOTA) group have developed the ADNEX (The Assessment of Different NEoplasias in the adneXa) model to predict the risk that an ovarian mass is benign, borderline, stag...
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Article
Open AccessPhase I trial outcomes in older patients with advanced solid tumours
This study had two aims: (a) to test the hypothesis that advanced age is associated with lower levels of tolerability and clinical benefit to experimental Phase I trial agents; (b) to assess the validity of th...
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Article
Open AccessLymphoma incidence, survival and prevalence 2004–2014: sub-type analyses from the UK’s Haematological Malignancy Research Network
Population-based information about cancer occurrence and survival are required to inform clinical practice and research; but for most lymphomas data are lacking.
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Open AccessComment on ‘Childhood leukaemia and socioeconomic status in England and Wales 1976–2005: evidence of higher incidence in relatively affluent communities persists over time’
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Article
Open AccessSevere reaction to radiotherapy for breast cancer as the presenting feature of ataxia telangiectasia
Severe early and late radiation reaction to radiotherapy is extremely rare in breast cancer patients. Such a reaction prompted an investigation into a 44-year-old mother (patient A-T213).
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Open AccessIncidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network
Ascertainment of cases and disease classification is an acknowledged problem for epidemiological research into haematological malignancies.
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Article
Open AccessHodgkin's lymphoma and infection: findings from a UK case–control study
Between 1998 and 2003, 214 people with Hodgkin's lymphoma and 214 controls randomly selected from population registers in the north of England (after matching for age and sex) were recruited and their primary ...
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Article
Open AccessScreening for social difficulties in cancer patients: clinical utility of the Social Difficulties Inventory
Guidelines for psychosocial support have been developed, but there are no standard approaches in routine oncology practice to identify patients experiencing social difficulties. We have designed and evaluated ...
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Article
Open AccessPsychosocial difficulties, deprivation and cancer: three questionnaire studies involving 609 cancer patients
The aim of the study is to investigate associations between deprivation and self-reported social difficulties and psychological distress in cancer patients. A total of 304 men and 305 women (age range 18–88 ye...
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Open AccessReassurance and the anxious cancer patient
Many cancer patients are anxious even when disease is in remission. Anxiety about health, ‘health anxiety’, has distinct features, notably seeking medical reassurance about symptoms. Doctors may then communica...
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Article
Open AccessPotential role of endocrine gastrin in the colonic adenoma carcinoma sequence
The role of hyper-gastrinaemia in the incidence of colonic cancer remains to be clarified. The aim of this study was to determine whether cholecystokinin-2 (CCK-2) receptor expression predicts the sensitivity ...
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Article
Open AccessValidating automated screening for psychological distress by means of computer touchscreens for use in routine oncology practice
The aim of the study was to confirm the validity of using touchscreen computers for screening for clinically significant levels of distress among cancer patients in routine oncology practice. The Hospital Anxi...
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Article
Open AccessPathology characteristics that optimize outcome prediction of a breast screening trial
The ability of pathology characteristics to predict outcome was tested with the 1029 cancers accumulated in the Edinburgh Randomized Trial of breast screening after 14 years follow-up. The majority (55.7%) wer...
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Article
Evaluation of methylation analysis for diagnostic testing in 258 referrals suspected of Prader-Willi or Angelman syndromes
Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are distinct neurodevelopmental disorders with interrelated genetic mechanisms because genomic imprinting within the chromosome 15q11–13 region affects b...
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Article
Susceptibility to multiple cutaneous basal cell carcinomas: significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender
The factors that determine development of single and multiple primary cutaneous basal cell carcinomas (BCCs) are unclear. We describe a case-control study firstly, to examine the influence of allelism at the g...
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Article
Investigations with fluorescence in situ hybridization (FISH) demonstrate loss of the telomeres on the reciprocal chromosome in three unbalanced translocations involving chromosome 15 in the Prader-Willi and Angelman syndromes
Two patients with classical features of Angelman syndrome (AS) and one with Prader-Willi syndrome (PWS) had unbalanced reciprocal translocations involving the chromosome 15 proximal long arm and the telomeric ...
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Article
Does it matter where you live? Treatment variation for breast cancer in Yorkshire
Over 27,000 patients with breast cancer were identified from cancer registry data from 1978 to 1992 and differences in treatment practice across the 16 districts of Yorkshire studied. A total of 50 surgeons tr...
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Article
The Edinburgh randomised trial of breast cancer screening: results after 10 years of follow-up
The Edinburgh Randomised Trial of Breast Cancer Screening recruited 44,288 women aged 45-64 years into the initial cohort of the trial during 1978-81, and 10 years of follow-up is now complete. A total of 22,9...
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Article
Familial unbalanced translocation t(8;15)(p23.3;q11) with uniparental disomy in Angelman syndrome
A 29-year-old male with Angelman syndrome and an unbalanced reciprocal translocation, 45,XY,-8,-15,+der(8),t(8;15)(p23.3;q11)pat, was evaluated with DNA studies. These showed the underlying mechanism to be pat...
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Article
Selective immunotherapy of small cell cancer xenografts using 131I-labelled SWA11 antibody
Intact SWA11 antibody was evaluated as a potential radioimmunotherapeutic agent against small cell lung cancer xenografts in a nude mouse model system. 131I-labelled SWA11 was given either in a single injectio...
