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  1. Article

    Open Access

    LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway

    Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. In this study, we examined the effects of a ne...

    H Hasegawa, Y Yamada, K Tsukasaki, N Mori, K Tsuruda, D Sasaki, T Usui, A Osaka… in Leukemia (2011)

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  2. No Access

    Article

    Synthesis of bioactive PMMA bone cement via modification with methacryloxypropyltri- methoxysilane and calcium acetate

    Bone cement consisting of polymethylmethacrylate (PMMA) powder and methylmethacrylate (MMA) liquid is clinically used for fixation of implants such as artificial hip joints. However, it does not show bone-bond...

    A. Mori, C. Ohtsuki, T. Miyazaki, A. Sugino… in Journal of Materials Science: Materials in… (2005)

  3. No Access

    Article

    Microstructure analysis of calcium phosphate formed in tendon

    The surface of soft tendon tissue has been modified using calcium phosphate in order for the tendon to directly connect with hard bone and reconstruct an injured ligament. Calcium phosphate was coated onto the...

    I. Yamaguchi, T. Kogure, M. Sakane… in Journal of Materials Science: Materials in… (2003)

  4. No Access

    Article

    Synthesis of PDMS-Based Porous Materials for Biomedical Applications

    Polydimethylsiloxane (PDMS) and tetraethoxysilane (TEOS)-based porous organically modified silicates (ORMOSILs) for biomedical applications were synthesized through a sol-gel process, using sucrose particles a...

    T. Yabuta, E.P. Bescher, J.D. Mackenzie… in Journal of Sol-Gel Science and Technology (2003)

  5. No Access

    Article

    Development of bioactive PMMA-based cement by modification with alkoxysilane and calcium salt

    Poly (methyl methacylate) (PMMA) bone cement is one of the popular bone-repairing materials for fixation of artificial hip joints. Significant problems on the PMMA bone cement are caused by loosening at the in...

    C. Ohtsuki, T. Miyazaki, M. Kyomoto… in Journal of Materials Science: Materials in… (2001)

  6. No Access

    Article

    Fluidity of a slurry of the graphite powder coated with Al2O3-based metal oxides

    K. Kawabata, H. Yoshimatsu, E. Fujii, K. Hiragushi… in Journal of Materials Science Letters (2001)

  7. No Access

    Article

    Apatite Formation on Electrochemically Treated Titanium

    Apatite formation on artificial materials in a body environment is the prerequisite condition for showing bioactivity i.e. bone-bonding ability. A specific hydrated silica or titania gel has the ability of apa...

    K. Tsuru, S. Takemoto, S. Hayakawa, A. Osaka in MRS Online Proceedings Library (1999)

  8. No Access

    Article

    Properties and catalytic activity of NOx reduction of alumina-titania catalysts prepared by sol-gel method

    The alumina-titania catalysts were prepared from various alumina and titania sources by sol-gel method, which were metal alkoxide and metal alkoxide modified with organic groups. Specific surface area, pore si...

    K. Kawabata, H. Yoshimatsu, K. Fujiwara, T. Yabuki… in Journal of Materials Science (1999)

  9. No Access

    Article

    Ultrasonic implantation of calcium metasilicate glass particles into PMMA

    Polymer materials for clinical applications should be bioactive and have a bone-bonding ability. In order to provide poly(methyl methacrylate) (PMMA) with bioactivity, granules (<45 μm) of a bioactive glass 50...

    K Tsuru, S Hayakawa, C Ohtsuki, A Osaka in Journal of Materials Science: Materials in… (1998)

  10. No Access

    Article

    Bioactivity of sol–gel derived organically modified silicates: Part I: In vitro examination

    Bioactivity was investigated for several organically modified silicates (Ormosils) prepared through sol–gel processes. Ca(II)-free samples were biocompatible only, but Ca(II)containing samples were bioactive a...

    K TSURU, C OHTSUKI, A OSAKA, T IWAMOTO… in Journal of Materials Science: Materials in… (1997)

  11. No Access

    Article

    Synthesis of Bioactive Ormosils by the Sol-Gel Method

    Bioactive ORMOSILS (Organically Modified Silicates) were synthesized by a sol-gel method, with tetraethoxysilane (TEOS) and polydimethylsiloxane (PDMS). Ca(II) ions were incorporated into the ormosil monoliths...

    K. Tsuru, C. Ohtsuki, A. Osaka, T. Iwamoto… in MRS Online Proceedings Library (1996)

  12. No Access

    Article

    Local structure around aluminium in the glasses of the system Al2O3-PbO-CdO

    J. Fu, A. Osaka, T. Nanba, Y. Miura in Journal of Materials Science Letters (1993)

  13. No Access

    Article

    Calcium apatite prepared from calcium hydroxide and orthophosphoric acid

    Calcium hydroxyapatite has been prepared due to a direct precipitation reaction between 0.3m orthophosphoric acid solution and 0.1 mol calcium hydroxide dispersed in 200 ml water. The effect of the addition rate ...

    A. Osaka, Y. Miura, K. Takeuchi, M. Asada… in Journal of Materials Science: Materials in… (1991)