46 Result(s)

Article

The Limitations of Frailty Assessment Tools in ANCA-Associated Vasculitis

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) can be associated with a high burden of morbidity and mortality in an ageing population. It is increasingly recognised that individualise...

Dr Lauren Floyd, L. Byrne, A. D. Morris, A. C. Nixon… in The Journal of Frailty & Aging (2023)

Article

A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough

The most common side effect of angiotensin-converting enzyme inhibitor (ACEi) drugs is cough. We conducted a genome-wide association study (GWAS) of ACEi-induced cough among 7080 subjects of diverse ancestries...

J D Mosley, C M Shaffer, S L Van Driest, P E Weeke… in The Pharmacogenomics Journal (2016)

Article

Risk stratification for diabetic eye screening. Reply to Stratton I. M. and Aldington S. J. [letter]

H. C. Looker, S. O. Nyangoma, D. T. Cromie, J. A. Olson, G. P. Leese… in Diabetologia (2014)

Article

Predicted impact of extending the screening interval for diabetic retinopathy: the Scottish Diabetic Retinopathy Screening programme

The aim of our study was to identify subgroups of patients attending the Scottish Diabetic Retinopathy Screening (DRS) programme who might safely move from annual to two yearly retinopathy screening.

H. C. Looker, S. O. Nyangoma, D. T. Cromie, J. A. Olson, G. P. Leese… in Diabetologia (2013)

Article

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with...

A. Albrechtsen, N. Grarup, Y. Li, T. Sparsø, G. Tian, H. Cao, T. Jiang… in Diabetologia (2013)

Article

Area-based socioeconomic status, type 2 diabetes and cardiovascular mortality in Scotland

The aim of this study was to explore the relationships between type 2 diabetes mellitus, area-based socioeconomic status (SES) and cardiovascular disease mortality in Scotland.

C. A. Jackson, N. R. V. Jones, J. J. Walker, C. M. Fischbacher… in Diabetologia (2012)

Article

Hospitalised hip fracture risk with rosiglitazone and pioglitazone use compared with other glucose-lowering drugs

Current drug labels for thiazolidinediones (TZDs) warn of increased fractures, predominantly for distal fractures in women. We examined whether exposure to TZDs affects hip fracture in women and men and compar...

H. M. Colhoun, S. J. Livingstone, H. C. Looker, A. D. Morris, S. H. Wild… in Diabetologia (2012)

Article

The effect of deprivation and HbA_1c on admission to hospital for diabetic ketoacidosis in type 1 diabetes

Diabetic ketoacidosis is a potentially life-threatening complication of diabetes and has a strong relationship with HbA_1c. We examined how socioeconomic group affects the likelihood of admission to hospital for d...

L. Govan, E. Maietti, B. Torsney, O. Wu, A. Briggs, H. M. Colhoun… in Diabetologia (2012)

Article

Diabetic retinopathy at diagnosis of type 2 diabetes in Scotland

The aim of this study was to examine the prevalence of and risk factors for diabetic retinopathy in people with newly diagnosed type 2 diabetes mellitus, using Scottish national data.

H. C. Looker, S. O. Nyangoma, D. Cromie, J. A. Olson, G. P. Leese, M. Black… in Diabetologia (2012)

Article

Do men develop type 2 diabetes at lower body mass indices than women?

To describe the associations between age, sex and BMI at diagnosis of type 2 diabetes, and test the hypothesis that men are diagnosed with diabetes at lower average BMI than women of similar age.

J. Logue, J. J. Walker, H. M. Colhoun, G. P. Leese, R. S. Lindsay… in Diabetologia (2011)

Article

Inpatient costs for people with type 1 and type 2 diabetes in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group

The rising prevalence of diabetes worldwide has increased interest in the cost of diabetes. Inpatient costs for all people with diabetes in Scotland were investigated.

L. Govan, O. Wu, A. Briggs, H. M. Colhoun, J. A. McKnight, A. D. Morris… in Diabetologia (2011)

Article

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility

Rare mutations in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4α (HNF-4A), account for ~5% of cases of MODY and more frequent variants in this gene may be involved in multifactoria...

B. Jafar-Mohammadi, C. J. Groves, A. P. Gjesing, B. M. Herrera, W. Winckler… in Diabetologia (2011)

Article

The effect of different doses of vitamin D₃ on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial

Low 25-hydroxyvitamin D levels predict future cardiovascular events and are common in patients with type 2 diabetes. We compared the effect of 100,000 and 200,000 IU doses of vitamin D₃ on endothelial function, b...

M. D. Witham, F. J. Dove, M. Dryburgh, J. A. Sugden, A. D. Morris… in Diabetologia (2010)

Article

Genetic association analysis of LARS2 with type 2 diabetes

LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the low-frequency H324Q (rs71645922) variant (minor allele frequency [MAF] 3.0%). Howeve...

E. Reiling, B. Jafar-Mohammadi, E. van ’t Riet, M. N. Weedon… in Diabetologia (2010)

Article

A cohort study of the risk of cancer associated with type 2 diabetes

There is evidence to suggest that diabetes may increase the risk of incidence and mortality from cancer.

A A Ogunleye, S A Ogston, A D Morris, J M M Evans in British Journal of Cancer (2009)

Article

Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes

There are strong associations between measures of inflammation and type 2 diabetes, but the causal directions of these associations are not known. We tested the hypothesis that common gene variants known to al...

S. Rafiq, D. Melzer, M. N. Weedon, H. Lango, R. Saxena, L. J. Scott… in Diabetologia (2008)

Article

Spironolactone for poorly controlled hypertension in type 2 diabetes: conflicting effects on blood pressure, endothelial function, glycaemic control and hormonal profiles

Aldosterone antagonism improves endothelial function (and reduces deaths) in chronic heart failure. It is not known whether similar effects occur in other high-risk groups such as patients with diabetes and hy...

K. Swaminathan, J. Davies, J. George, N. S. Rajendra, A. D. Morris… in Diabetologia (2008)

Article

Gradual reactivation of vascular angiotensin I to angiotensin II conversion during chronic ACE inhibitor therapy in patients with diabetes mellitus

In chronic heart failure there is gradual reactivation of vascular tissue angiotensin I (AI) to angiotensin II (AII) conversion over time in patients taking chronic ACE inhibitor therapy. However, it remains u...

D. C. Sharman, A. D. Morris, A. D. Struthers in Diabetologia (2007)

Article

TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels

The gene encoding transcription factor 7-like 2 (TCF7L2) has been identified as a type 2 diabetes locus from genome-wide linkage studies and subsequent association analysis. We investigated the role of two common...

C. H. Kimber, A. S. F. Doney, E. R. Pearson, M. I. McCarthy… in Diabetologia (2007)