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Article
Open AccessCancer Grade Model: a multi-gene machine learning-based risk classification for improving prognosis in breast cancer
Prognostic stratification of breast cancers remains a challenge to improve clinical decision making. We employ machine learning on breast cancer transcriptomics from multiple studies to link the expression of ...
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Article
Open AccessDetecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor
Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clini...
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Article
Osteonecrosis of the jaw (ONJ): diagnosis and management in 2015
Osteonecrosis of the jaw (ONJ) has been associated with the use of aminobisphosphonates and denosumab. The vast majority (>90 %) of cases occur in the oncology patient population receiving high doses of intrav...
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Article
Open AccessPsychotropic Drug Use Before And During Physical Restraint For Mechanically Ventilated Critically Ill Adults
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Article
Reliability of the spine adverse events severity system (SAVES) for individuals with traumatic spinal cord injury
Test–retest analysis.
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Article
Use of the Spine Adverse Events Severity System (SAVES) in patients with traumatic spinal cord injury. A comparison with institutional ICD-10 coding for the identification of acute care adverse events
Observational cohort comparison.
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Article
Open AccessHIV-1 envelope trimer elicits higher neutralizing antibody responses than monomeric gp120
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Article
Erratum: Cell type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR
Correction to: Oncogene (2005) 24, 1860–1872; doi:10.1038/sj.onc.1208315; published online 31 January 2005 Since the publication of the above manuscript, the authors have identified an error in the author list...
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Article
Could a policy of provision of hip protectors to elderly nursing home residents result in cost savings in acute hip fracture care? The case of Ontario, Canada
Hip fractures are an important problem in nursing homes. Hip protectors are external devices that decrease the risk of hip fracture in elderly nursing home residents. We estimated the overall healthcare cost s...
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Article
A small-molecule inhibitor of skeletal muscle myosin II
We screened a small-molecule library for inhibitors of rabbit muscle myosin II subfragment 1 (S1) actin-stimulated ATPase activity. The best inhibitor, N-benzyl-p-toluene sulphonamide (BTS), an aryl sulphonamide,...
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Article
Decreased bone mineral density is common after autologous blood or marrow transplantation
Survivors of autologous blood or marrow transplantation (ABMT) are predisposed to decreased bone mineral density (BMD), but data are lacking on the incidence and risk factors for this condition. Therefore, we ...
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Pharmacologic Immunosuppressants in Xenotransplantation
Since the late 1980s a number of new immunosuppressive agents with novel mechanisms of action and distinct therapeutic efficacies have emerged [1–6]. Many of these offer the ability to prolong xenograft surviv...
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Article
Waterford Surgical October Club Proceedings of meeting held Saturday, 30th October, 1993
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Article
Primary mixed neuroendocrine and mucinous carcinoma of the ovary
A rare case of mixed carcinoma of ovary with a predominant malignant neuroendocrine and a lesser mucinous tumor component is described. Extensive areas of enteric-type epithelium containing endocrine cells wer...
