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  1. No Access

    Article

    ANKRD55 and DHCR7 are novel multiple sclerosis risk loci

    Multiple sclerosis (MS) shares some risk genes with other disorders hallmarked by an autoimmune pathogenesis, most notably IL2RA and CLEC16A. We analyzed 10 single-nucleotide polymorphisms (SNPs) in nine risk gen...

    I Alloza, D Otaegui, A Lopez de Lapuente, A Antigüedad, J Varadé… in Genes & Immunity (2012)

  2. No Access

    Article

    A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis

    Cytokine and cytokine receptor genes, including IL2RA, IL7R and IL12A, are known risk factors for multiple sclerosis (MS). Excitotoxic oligodendroglial death mediated by glutamate receptors contributes to demyeli...

    K Vandenbroeck, J Alvarez, B Swaminathan, I Alloza, F Matesanz… in Genes & Immunity (2012)

  3. No Access

    Article

    Members 6B and 14 of the TNF receptor superfamily in multiple sclerosis predisposition

    TNFRSF6B and TNFRSF14 genes were recently associated with Crohn's disease and rheumatoid arthritis. TNFRSF14 is known as herpes virus entry mediator (HVEM), and herpes viruses have been involved in the aetiology ...

    F Blanco-Kelly, R Alvarez-Lafuente, A Alcina, M M Abad-Grau… in Genes & Immunity (2011)

  4. No Access

    Article

    Replication of top markers of a genome-wide association study in multiple sclerosis in Spain

    Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with presumed autoimmune origin, triggered by genetic and environmental risk factors. A recent genome-wide association st...

    M L Cavanillas, O Fernández, M Comabella, A Alcina, M Fedetz… in Genes & Immunity (2011)

  5. No Access

    Article

    The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis

    Genome-wide association studies (GWAS) have revealed that different diseases share susceptibility variants. Twelve single-nucleotide polymorphisms (SNPs) previously associated with different immune-mediated di...

    A Alcina, K Vandenbroeck, D Otaegui, A Saiz, J R Gonzalez, O Fernandez… in Genes & Immunity (2010)

  6. No Access

    Article

    STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility

    STAT3 (signal transducer and activator of transcription 3) signaling is a critical component of Th17-dependent autoimmune processes. Genome-wide association studies (GWAS) have revealed the role of the STAT3 gene...

    M C Cénit, A Alcina, A Márquez, J L Mendoza, M Díaz-Rubio… in Genes & Immunity (2010)

  7. No Access

    Article

    Protein tyrosine phosphatase gene (PTPN22) polymorphism in multiple sclerosis

    F. Matesanz, B. Rueda, G. Orozco, O. Fernandez, L. Leyva, A. Alcina… in Journal of Neurology (2005)