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Open AccessBenchmarking computational variant effect predictors by their ability to infer human traits
Computational variant effect predictors offer a scalable and increasingly reliable means of interpreting human genetic variation, but concerns of circularity and bias have limited previous methods for evaluati...
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Article
Open AccessUtilizing intelligent technologies in construction and demolition waste management: From a systematic review to an implementation framework
The rapid increase in global urbanization, along with the growth of the construction industry, highlights the urgent need for effective management of construction and demolition (C&D) waste. Intelligent techno...
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Article
Open AccessExtended depth of focus IOL in eyes with different axial myopia and targeted refraction
To evaluate the objective visual outcomes following implantation of extended depth of focus intraocular lens (EDOF IOL) in individuals with varying axial lengths (AL) and targeted refraction.
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Article
Open AccesslncRNA RMST is associated with the progression and prognosis of gastric cancer via miR-204-5p
Exploring novel biomarkers for gastric cancer holds promise for enhancing patients’ therapy and survival rates. lncRNAs and miRNAs have emerged as important biomarkers for various human cancers. However, the r...
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Article
Open AccessChasing weakly-bound biological water in aqueous environment near the peptide backbone by ultrafast 2D infrared spectroscopy
There has been a long-standing debate as to how many hydrogen bonds a peptide backbone amide can form in aqueous solution. Hydrogen-bonding structural dynamics of N-ethylpropionamide (a β-peptide model) in water ...
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Open AccessCorrection to: The global, regional, and national burden of colorectal cancer in 204 countries and territories from 1990 to 2019
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Open AccessImpact assessment of construction waste policy intensity on environmental efficiency based on system generalized method of moments
With the acceleration of urbanization in recent years, China has witnessed large-scale construction across its provinces, generating massive amounts of construction waste that pose challenges to environmental ...
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Article
Open AccessThe global, regional, and national burden of colorectal cancer in 204 countries and territories from 1990 to 2019
We aimed to estimate the global burden of colorectal cancer (CRC) between 1990 and 2019.
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Open AccessGbdmr: identifying differentially methylated CpG regions in the human genome via generalized beta regressions
DNA methylation is a biochemical process in which a methyl group is added to the cytosine-phosphate-guanine (CpG) site on DNA molecules without altering the DNA sequence. Multiple CpG sites in a certain genome...
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Article
Open AccessRelationship between hemolysis and lipid oxidation in red blood cell-spiked fish muscle; dependance on pH and blood plasma
The relationship between hemolysis and lipid oxidation was explored in red blood cell (RBCs)-spiked washed cod mince (WCM). At pH 6.8 and 3 ± 1 °C, intact RBCs (71 µM Hb) delayed lipid oxidation by 1 day compa...
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Open AccessDeep evolutionary fusion neural network: a new prediction standard for infectious disease incidence rates
Previously, many methods have been used to predict the incidence trends of infectious diseases. There are numerous methods for predicting the incidence trends of infectious diseases, and they have exhibited va...
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Article
Open AccessA chromosome-level genome assembly of a free-living white-crowned sparrow (Zonotrichia leucophrys gambelii)
The white-crowned sparrow, Zonotrichia leucophrys, is a passerine bird with a wide distribution and it is extensively adapted to environmental changes. It has historically acted as a model species in studies on a...
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Open AccessIdentification of associated risk factors for serological distribution of hepatitis B virus via machine learning models
The provincial-level sero-survey was launched to learn the updated seroprevalence of hepatitis B virus (HBV) infection in the general population aged 1–69 years in Chongqing and to assess the risk factors for ...
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Open AccessFinite element analysis and a pilot study of different fixation constructs for Danis-Weber A and B lateral malleolus fractures
Displaced lateral malleolus fractures are typically stabilised through open reduction and internal fixation. The biomechanically and clinically efficacy of locking plates and lag screws, particularly in Weber ...
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Open AccessStructural variants involved in high-altitude adaptation detected using single-molecule long-read sequencing
Structural variants (SVs), accounting for a larger fraction of the genome than SNPs/InDels, are an important pool of genetic variation, enabling environmental adaptations. Here, we perform long-read sequencing...
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Open AccessResearch on the control strategy of DC microgrids with distributed energy storage
As a supplement to large power grids, DC microgrids with new energy access are increasingly widely used. However, with the increasing proportion of new energy in DC microgrids, its output fluctuations directly...
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Article
Open AccessH3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome
The H3 methyltransferases ATXR5 and ATXR6 deposit H3.1K27me1 to heterochromatin to prevent genomic instability and transposon re-activation. Here, we report that atxr5 atxr6 mutants display robust resistance to G...
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Open AccessRobust fault diagnosis of a high-voltage circuit breaker via an ensemble echo state network with evidence fusion
Reliable mechanical fault diagnosis of high-voltage circuit breakers is important to ensure the safety of electric power systems. Recent fault diagnosis approaches are mostly based on a single classifier whose...
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Article
Open AccessREPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis
Osteoporosis is not well treated due to the difficulty of finding commonalities between the various types of it. Iron homeostasis is a vital component in supporting biochemical functions, and iron overload is ...
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Article
Open AccessKnockdown of PGC1α suppresses dysplastic oral keratinocytes proliferation through reprogramming energy metabolism
Oral potentially malignant disorders (OPMDs) are precursors of oral squamous cell carcinoma (OSCC). Deregulated cellular energy metabolism is a critical hallmark of cancer cells. Peroxisome proliferator-activa...
