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Article
Reward Function Design Method for Long Episode Pursuit Tasks Under Polar Coordinate in Multi-Agent Reinforcement Learning
Multi-agent reinforcement learning has recently been applied to solve pursuit problems. However, it suffers from a large number of time steps per training episode, thus always struggling to converge effectivel...
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Article
Open AccessA positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression
The aberrant expression of phosphofructokinase-platelet (PFKP) plays a crucial role in the development of various human cancers by modifying diverse biological functions. However, the precise molecular mechani...
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Article
Open AccessLight-driven C–H activation mediated by 2D transition metal dichalcogenides
C–H bond activation enables the facile synthesis of new chemicals. While C–H activation in short-chain alkanes has been widely investigated, it remains largely unexplored for long-chain organic molecules. Here...
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Article
Open AccessFitness effects of synthetic and natural diet preservatives on the edible insect Bombyx mori
Silkworm pupae as widely consumed insect products are good biosources of protein and micronutrients. Silkworm rearing throughout the year can be achieved by feeding them an artificial diet instead of native pl...
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Article
Open AccessCholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma
Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated promising efficacy in early trials for relapsed/refractory diffuse large B cell lymphoma (DLBCL). However, its efficacy in treating primary ref...
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Article
Translocator protein (18 kDa) positron emission tomography imaging as a biomarker of neuroinflammation in epilepsy
Increasing evidence indicate that neuroinflammation triggered by glial cells plays a significant role in epileptogenesis. To this effect, the overexpression of translocator protein 18 kDa (TSPO) in activated m...
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Article
Open AccessGenetic variations of low-density lipoprotein cholesterol on metabolic disorders in obstructive sleep apnea
The study aimed to explore the relationship between low-density lipoprotein cholesterol (LDL-C) genetic variants and obstructive sleep apnea (OSA) and its complications, including cardiovascular diseases (CVD)...
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Article
Enhanced electrode reaction for La0.8Sr0.2FeO3-δ-Sm0.2Ce0.8O1.9 composite cathode by barium carbonate nanoparticles as a synergistic catalyst
BaCO3 nanoparticles are demonstrated as outstanding catalysts for high-temperature oxygen reduction reaction on the La0.8Sr0.2FeO3-δ (LSF)-Sm0.2Ce0.8O2−δ (SDC) cathode for solid oxide fuel cells (SOFCs). X-ray di...
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Article
Open AccessPhosphorylation of FOXK2 at Thr13 and Ser30 by PDK2 sustains glycolysis through a positive feedback manner in ovarian cancer
Ovarian cancer is one of the most common gynecological malignant tumors with insidious onset, strong invasiveness, and poor prognosis. Metabolic alteration, particularly aerobic glycolysis, which is tightly re...
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Article
Self-powered and self-sensing devices based on piezoelectric energy harvesting
Wearable devices, interactive human-machine interface equipment, wireless sensors, and small-scale cleaning devices play crucial roles in biomedical implantation, disease treatment, health monitoring, environm...
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Article
Open AccessTGF-β signaling regulates differentiation of MSCs in bone metabolism: disputes among viewpoints
Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into cells of different lineages to form mesenchymal tissues, which are promising in regard to treatment for bone diseases. Their oste...
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Article
Effects of Test-Specimen Boundary Conditions on the Interpretation of Stress–Strain Results for Hydraulic Asphalt Concrete
Determining the realistic shear stress–strain–strength behaviour of asphalt concrete is important when designing asphalt pavements and impervious asphalt linings, facings, and cores for dams and dykes. The beh...
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Article
Individual cerebellar metabolic connectome in patients with MTLE and NTLE associated with surgical prognosis
This study aimed to comprehensively explore the different metabolic connectivity topological changes in MTLE and NTLE, as well as their association with surgical outcomes.
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Article
Biportal endoscopy-assisted lateral mass screw fixation using a third portal
The technique of spinal decompression under endoscopy has been widely applied, but reports on endoscopic cervical fixation are rare. The unilateral biportal endoscopic (UBE) technique stands out for its lesser...
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Article
Open AccessIndependent relationship between sleep apnea-specific hypoxic burden and glucolipid metabolism disorder: a cross-sectional study
Obstructive sleep apnea (OSA) is associated with abnormal glucose and lipid metabolism. However, whether there is an independent association between Sleep Apnea-Specific Hypoxic Burden (SASHB) and glycolipid m...
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Article
Open AccessMiR-6839-5p inhibits cell proliferation, migration and invasion; a possible correlation with the suppressing VEGFA expression in human chondrosarcoma cells
MicroRNAs play an important role in the proliferation, invasion, and metastasis of malignancy. In previous studies (detailed in our previous paper), the expression of miR-6839-5p was significantly increased in...
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Article
Identification and validation of microbial biomarkers from cross-cohort datasets using xMarkerFinder
Microbial signatures have emerged as promising biomarkers for disease diagnostics and prognostics, yet their variability across different studies calls for a standardized approach to biomarker research. Theref...
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Article
Open AccessImpact of treatment interval between neoadjuvant immunochemotherapy and surgery in lung squamous cell carcinoma
The optimal timing for surgery following neoadjuvant immunochemotherapy for lung squamous cell carcinoma appears to be a topic of limited data. Many clinical studies lack stringent guidelines regarding this ti...
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Article
Anticancer Peptide MCP-1 Induces Ferroptosis in Liver Cancer HCCLM3 Cells by Targeting FOXM1/ALOXE3 Signal Pathway
FOXM1 is a crucial oncogenic transcription factor involved in almost all cancer hallmark pathways across all cancer types. Our previous work had found that FOXM1 targeted peptide P201 can strongly inhibit the ...
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Article
Open AccessUnilateral biportal endoscopy via two different approaches for upper lumbar disc herniation: a technical note
The traditional surgical procedures for upper lumbar disc herniation (ULDH) usually lead to frequent complications. We aim to investigate the clinical efficacy of the unilateral biportal endoscopy (UBE) techni...
