23,854 Result(s)
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Bioinformatics
Biomedical Engineering/Biotechnology
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Open AccessResearch Progress on Bio-inspired Flap**-Wing Rotor Micro Aerial Vehicle Development
Flap**-wing rotor (FWR) is an innovative bio-inspired micro aerial vehicle capable of vertical take-off and landing. This unique design combines active flap** motion and passive wing rotation around a vert...
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Open AccessTemplate-independent enzymatic synthesis of RNA oligonucleotides
RNA oligonucleotides have emerged as a powerful therapeutic modality to treat disease, yet current manufacturing methods may not be able to deliver on anticipated future demand. Here, we report the development...
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Enzymatic synthesis of RNA oligonucleotides
Research on enzymatic RNA synthesis has long been eclipsed by work on DNA—but a new method provides a leap forward for RNA.
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Open AccessPrecise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA
Recruiting the endogenous editing enzyme adenosine deaminase acting on RNA (ADAR) with tailored guide RNAs for adenosine-to-inosine (A-to-I) RNA base editing is promising for safely manipulating genetic inform...
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Erratum to: A Comprehensive Review: Recent Developments of Biomimetic Sensors
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CAR-Ts sweep into autoimmunity
Biotechs are equip** CAR-T cells to destroy B cells — not to treat blood cancers, but to take on multiple sclerosis and a raft of autoimmune disorders.
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Open AccessAn Intrusion Detection System on The Internet of Things Using Deep Learning and Multi-objective Enhanced Gorilla Troops Optimizer
In recent years, developed Intrusion Detection Systems (IDSs) perform a vital function in improving security and anomaly detection. The effectiveness of deep learning-based methods has been proven in extractin...
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A Modified Genetic Algorithm for Combined Heat and Power Economic Dispatch
Combined Heat and Power Economic Dispatch (CHPED) is an important problem in the energy field, and it is beneficial for improving the utilization efficiency of power and heat energies. This paper proposes a Mo...
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Development and Performance Analysis of Pneumatic Variable Stiffness Imitation Dolphin Tail Actuator
It has been demonstrated that the flexibility of the structure can enhance the kinematic performance of the underwater bionic robotic fish. Furthermore, the thrust of the underwater robotic fish can be further...
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Glass Sponge-inspired Auxetic Mechanical Metamaterials for Energy Absorption
The Auxetic Structure (AS) exhibits significant densification strain due to its concave cell architecture, functioning as an effective energy-absorbing metamaterial. However, its limited plateau stress hampers...
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Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency
The use of modified nucleotides to suppress the interferon response and maintain translation of self-amplifying RNA (saRNA), which has been achieved for mRNA, has not yet succeeded. We identify modified nucleo...
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Gait Characteristics and Adaptation Strategies of Ants with Missing Legs
This paper systematically studies the movement behavior changes of Camponotus japonicus under one or two leg injuries. Firstly, a linear motion channel matching the size of the ants’ legs was designed, and the...
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Open AccessProteome-scale tagging and functional screening in mammalian cells by ORFtag
The systematic determination of protein function is a key goal of modern biology, but remains challenging with current approaches. Here we present ORFtag, a versatile, cost-effective and highly efficient metho...
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Open AccessMicrosecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs
Detecting microsecond structural perturbations in biomolecules has wide relevance in biology, chemistry and medicine. Here we show how MHz repetition rates at X-ray free-electron lasers can be used to produce ...
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Programming tumor evolution with selection gene drives to proactively combat drug resistance
Most targeted anticancer therapies fail due to drug resistance evolution. Here we show that tumor evolution can be reproducibly redirected to engineer therapeutic opportunity, regardless of the exact ensemble ...
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Open AccessSystematic comparison of sequencing-based spatial transcriptomic methods
Recent developments of sequencing-based spatial transcriptomics (sST) have catalyzed important advancements by facilitating transcriptome-scale spatial gene expression measurement. Despite this progress, effor...
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Evolutionary gambit to defeat drug resistance in cancer
A therapeutic strategy harnesses evolutionary dynamics to overcome tumor resistance to targeted therapies.
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CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells
Dynamic imaging of genomic loci is key for understanding gene regulation, but methods for imaging genomes, in particular non-repetitive DNAs, are limited. We developed CRISPRdelight, a DNA-labeling system base...
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Open Accessquantms: a cloud-based pipeline for quantitative proteomics enables the reanalysis of public proteomics data
The volume of public proteomics data is rapidly increasing, causing a computational challenge for large-scale reanalysis. Here, we introduce quantms (https://quant,ms.org/
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Editor’s pick: Unnatural Products
Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year. Unnatural Products is rewriting the rules for potent oral therapies.
