52 Result(s)
within
**wen Su
Life Sciences
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Article
Open AccessDUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling
DUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by dephosphorylation. Our study demonstrated that decreased DUSP22 expression ...
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Open AccessCDKN2A promoter methylation enhances self-renewal of glioblastoma stem cells and confers resistance to carmustine
Glioblastoma, a highly aggressive form of brain cancer, poses significant challenges due to its resistance to therapy and high recurrence rates. This study aimed to investigate the expression and functional im...
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Open AccessIntegrated analysis of HSP20 genes in the develo** flesh of peach: identification, expression profiling, and subcellular localization
Plant HSP20s are not only synthesized in response to heat stress but are also involved in plant biotic and abiotic stress resistance, normal metabolism, development, differentiation, survival, ripening, and de...
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Open AccessExogenous auxin regulates the growth and development of peach fruit at the expansion stage by mediating multiple-hormone signaling
Fruit expansion stage is crucial to fruit yield and quality formation, and auxin plays a significant role by mediating multi-hormone signals during fruit expansion. However, till now, it is still unclear of th...
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Analysis of BhAPRR2 allele variation, chlorophyll content, and chloroplast structure of different peel colour varieties of wax gourd (Benincasa hispida) and development of molecular markers
In this study, four non-synonymous mutations and one 3-base insertion were found in the BhAPRR2 sequences of four wax gourds with different peel colour. The analysis of pigment content and chloroplast structure s...
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Open AccessGene enrichment and co-expression analysis shed light on transcriptional responses to Ralstonia solanacearum in tomato
Tomato (Solanum lycopersicum) is both an important agricultural product and an excellent model system for studying plant-pathogen interactions. It is susceptible to bacterial wilt caused by Ralstonia solanacearum
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Open AccessThe alteration of intestinal mucosal α-synuclein expression and mucosal microbiota in Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease but still lacks a preclinical strategy to identify it. The diagnostic value of intestinal mucosal α-synuclein (αSyn) in PD has not d...
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Open Accessm5C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization
The significance of 5-methylcytosine (m5C) methylation in human malignancies has become an increasing focus of investigation. Here, we show that m5C regulators including writers, readers and erasers, are predomin...
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High-density genetic map and quantitative trait loci map of fruit-related traits in wax gourd (Benincasa hispida)
Wax gourd (Benincasa hispida [Thunb] Cogn.) is an important horticultural crop in the Cucurbitaceae family that has high nutritive and medicinal value. We analysed quantitative trait loci (QTLs) related to the fr...
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Chlorogenic acid accumulation and related gene expression in peach fruit
To reveal the molecular mechanism in the accumulation of chlorogenic acids (CGAs) in peach (Prunus persica) fruit during growth and development, CGA contents in the flesh of the three peach cultivars ‘Ruiguang 18...
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Fine map** and identification of the candidate gene BFS for fruit shape in wax gourd (Benincasa hispida)
Non-synonymous mutations in the BFS gene, which encodes the IQD protein, are responsible for the shape of wax gourd fruits.
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Ancestral sequence reconstruction pinpoints adaptations that enable avian influenza virus transmission in pigs
Understanding the evolutionary adaptations that enable avian influenza viruses to transmit in mammalian hosts could allow better detection of zoonotic viruses with pandemic potential. We applied ancestral sequ...
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Open AccessIdentification of miRNAs-mediated seed and stone-hardening regulatory networks and their signal pathway of GA-induced seedless berries in grapevine (V. vinifera L.)
Stone-hardening stage is crucial to the development of grape seed and berry quality. A significant body of evidence supports the important roles of MicroRNAs in grape-berry development, but their specific mole...
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Genome sequencing and comparative genome analysis of 6 hypervirulent Klebsiella pneumoniae strains isolated in China
Hypervirulent Klebsiella pneumoniae (hvKP) has been increasingly reported over the past three decades and causes severe infections. To increase our understanding of hvKP at the genome level, genome sequencing and...
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Root-Associated Endophytic Bacterial Community Composition of Asparagus officinalis of Three Different Varieties
Asparagus (Asparagus officinalis L) is an economically important crop, rich in nutrients, and is also conducive to solving ecological and environmental problems. Plants may acquire benefits from root-associated e...
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Open AccessIntravenous injection of the oncolytic virus M1 awakens antitumor T cells and overcomes resistance to checkpoint blockade
Reversing the highly immunosuppressive tumor microenvironment (TME) is essential to achieve long-term efficacy with cancer immunotherapy. Despite the impressive clinical response to checkpoint blockade in mult...
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Open AccessDemethylation alters transcriptome profiling of buds and leaves in ‘Kyoho’ grape
Grape buds and leaves are directly associated with the physiology and metabolic activities of the plant, which is monitored by epigenetic modifications induced by environment and endogenous factors. Methylatio...
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Production and excretion of astaxanthin by engineered Yarrowia lipolytica using plant oil as both the carbon source and the biocompatible extractant
This study aimed to develop a bioprocess using plant oil as the carbon source for lipid-assimilating yeast to produce high-value astaxanthin. Using high-oleic safflower oil as a model, efficient cell growth an...
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Open AccessCellular senescence mediates the detrimental effect of prenatal dexamethasone exposure on postnatal long bone growth in mouse offspring
Prenatal dexamethasone exposure (PDE) induces low birth weight and retardation of fetal bone development which are associated with lower peak bone mass in adult offspring. Here we evaluated whether and how PDE...
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Open AccessPwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation
Telomere maintenance is critical for chromosome stability. Here we report that periodic tryptophan protein 1 (PWP1) is involved in regulating telomere length homeostasis. Pwp1 appears to be essential for mouse de...
