67 Result(s)

Article

Clinical associations with a polygenic predisposition to benign lower white blood cell counts

Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical conse...

Jonathan D. Mosley, John P. Shelley, Alyson L. Dickson… in Nature Communications (2024)

Article

Nortriptyline hydrochloride, a potential candidate for drug repurposing, inhibits gastric cancer by inducing oxidative stress by triggering the Keap1-Nrf2 pathway

Effective drugs for the treatment of gastric cancer (GC) are still lacking. Nortriptyline Hydrochloride (NTP), a commonly used antidepressant medication, has been demonstrated by numerous studies to have antit...

Chunyang Zhu, Yangyang Lu, Shasha Wang, Jialin Song, Yixin Ding… in Scientific Reports (2024)

Article

Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients

Idiopathic tinnitus is a common and complex disorder with no established cure. The CAABT (Cochleural Alternating Acoustic Beam Therapy CAABT), is a personalized sound therapy designed to target specific tinnit...

Chunli Liu, Jie Zhang, Zhiwei Qi, Wenhui Yue, Yujie Yuan, Tao Jiang… in Scientific Reports (2024)

Article

Sentiment analysis of video danmakus based on MIBE-RoBERTa-FF-BiLSTM

Danmakus are user-generated comments that overlay on videos, enabling real-time interactions between viewers and video content. The emotional orientation of danmakus can reflect the attitudes and opinions of v...

Jianbo Zhao, Huailiang Liu, Yakai Wang, Weili Zhang, **ao** Zhang… in Scientific Reports (2024)

Article

Contribution of uniparental disomy to fetal growth restriction: a whole-exome sequencing series in a prenatal setting

Fetal growth restriction (FGR), a leading cause of perinatal morbidity and mortality, is caused by fetal, maternal, and placental factors. Uniparental disomy (UPD) is a rare condition that leads to imprinting ...

Mengmeng Li, Na Hao, Yulin Jiang, Huili Xue, Yifang Dai… in Scientific Reports (2024)

Article

Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

African Americans have a significantly higher risk of develo** chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene...

Yask Gupta, David J. Friedman, Michelle T. McNulty, Atlas Khan… in Nature Communications (2023)

Article

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms

Genes act in concert with each other in specific contexts to perform their functions. Determining how these genes influence complex traits requires a mechanistic understanding of expression regulation across d...

Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson… in Nature Communications (2023)

Article

Prediction model and demonstration of regional agricultural carbon emissions based on Isomap–ACO–ET: a case study of Guangdong Province, China

Scientific analysis of regional agricultural carbon emission prediction models and empirical studies are of great practical significance to the realization of low-carbon agriculture, which can help revitalize ...

Yanwei Qi, Huailiang Liu, Jianbo Zhao in Scientific Reports (2023)

Article

Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection

The SARS-CoV-2 Omicron variant evades most currently approved neutralizing antibodies (nAbs) and caused drastic decrease of plasma neutralizing activity elicited by vaccination or prior infection, urging the n...

Yu Guo, Guangshun Zhang, Qi Yang, **aowei **e, Yang Lu… in Nature Communications (2023)

Article

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, Stavroula Kanoni… in Nature (2023)

Article

Enzymatic polymerization of enantiomeric _L−3,4-dihydroxyphenylalanine into films with enhanced rigidity and stability

_L−3,4-dihydroxyphenylalanine is an important molecule in the adhesion of mussels, and as an oxidative precursor of natural melanin, it plays an important role in living system. Here, we investigate the effect o.....

Yuhe Shen, Rongxin Su, Dongzhao Hao, **aojian Xu, Meital Reches… in Nature Communications (2023)

Article

Valorization of rice straw, sugarcane bagasse and sweet sorghum bagasse for the production of bioethanol and phenylacetylcarbinol

Open burning of agricultural residues causes numerous complications including particulate matter pollution in the air, soil degradation, global warming and many more. Since they possess bio-conversion potentia...

Rojarej Nunta, Charin Techapun, Sumeth Sommanee… in Scientific Reports (2023)

Article

Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity

Dynamic regulation of intestinal epithelial cell (IEC) differentiation is crucial for both homeostasis and the response to helminth infection. SIRT6 belongs to the NAD⁺-dependent deacetylases and has established ...

**wen **ong, Chenyan Yang, Wei-Qi He, Jiahui Yu, Yue **n… in Nature Communications (2022)

Article

Natural variation of DROT1 confers drought adaptation in upland rice

Upland rice is a distinct ecotype that grows in aerobic environments and tolerates drought stress. However, the genetic basis of its drought resistance is unclear. Here, using an integrative approach combining...

**ngming Sun, Haiyan **ong, Conghui Jiang, Dongmei Zhang… in Nature Communications (2022)

Article

Effects of modified atmosphere packaging on the postharvest quality of mulberry leaf vegetable

Fresh mulberry leaf vegetable is nutritive and becoming popular. However, available preservation technologies are deficient. In present work, the effects of two kinds of modified atmosphere packaging on postha...

Teng-da Yang, Yu-long Chen, Fan-kun Zeng, Ming-qiang Ye, Ling Wang… in Scientific Reports (2022)

Article

Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders

Clinical and epidemiological studies have shown that circulatory system diseases and nervous system disorders often co-occur in patients. However, genetic susceptibility factors shared between these disease ca...

**nyuan Zhang, Anastasia M. Lucas, Yogasudha Veturi… in Nature Communications (2022)

Article

Global impacts of future urban expansion on terrestrial vertebrate diversity

Rapid urban expansion has profound impacts on global biodiversity through habitat conversion, degradation, fragmentation, and species extinction. However, how future urban expansion will affect global biodiver...

Guangdong Li, Chuanglin Fang, Yingjie Li, Zhenbo Wang, Siao Sun… in Nature Communications (2022)

Article

Global monthly gridded atmospheric carbon dioxide concentrations under the historical and future scenarios

Increases in atmospheric carbon dioxide (CO₂) concentrations is the main driver of global warming due to fossil fuel combustion. Satellite observations provide continuous global CO₂ retrieval products, that revea...

Wei Cheng, Li Dan, **angzheng Deng, **ming Feng, Yongli Wang, **g Peng… in Scientific Data (2022)

Article

Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension

Discovering novel uses for existing drugs, through drug repurposing, can reduce the time, costs, and risk of failure associated with new drug development. However, prioritizing drug repurposing candidates for ...

Patrick Wu, Qi** Feng, Vern Eric Kerchberger, Scott D. Nelson… in Nature Communications (2022)