10 Result(s)
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**usheng Lu
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessClinical application of thioredoxin reductase as a novel biomarker in liver cancer
Hepatic cancer is often amenable to surgery, including percutaneous ablation, trans-arterial chemoembolization. However, in metastatic cases, surgery is often not an effective option. Chemotherapy as a convent...
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Article
Open AccessPublisher Correction: Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessEliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
There are disease-causing biohazards in the blood that cannot be treated with modern medicines. Here we show that an intelligently designed safe biomaterial can precisely identify, tow and dump a targeted bioh...
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Article
Open AccessDual blockage of both PD-L1 and CD47 enhances immunotherapy against circulating tumor cells
Carcinoma metastasis is triggered by a subpopulation of circulating tumor cells (CTCs). And single immune checkpoint therapy is not good enough to inhibit CTC-induced metastasis. Here, we demonstrate that simu...
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Article
Open AccessSex-related pharmacokinetic differences and mechanisms of metapristone (RU486 metabolite)
Metapristone is the primary metabolite of the abortifacient mifepristone (RU486), and is being developed as a safe and effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically ...
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Open AccessPharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention
Metapristone is the most predominant biological active metabolite of mifepristone and being developed as a novel cancer metastasis chemopreventive agent by us. Despite its prominent metastasis chemopreventive ...
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Article
Open AccessMultivalent Conjugation of Antibody to Dendrimers for the Enhanced Capture and Regulation on Colon Cancer Cells
Circulation tumor cells (CTCs) in the bloodstream of early-stage cancer patients carry the important information about valuable biomarkers and biological properties of primary tumor. However, detection and cap...
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Article
Open AccessSystems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: Comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex
Mifepristone (RU486), a synthetic steroid compound used as an abortifacient drug, has received considerable attention to its anticancer activity recently. To explore the possibility of using mifepristone as a ...
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Article
Open AccessSynergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis
Ursolic acid (UA) is a naturally bioactive product that exhibits potential anticancer effects. The relatively safe and effective molecule intrigued us to explore a way to further improve its anti-cancer activi...
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Open AccessNitric Oxide Inhibits Hetero-adhesion of Cancer Cells to Endothelial Cells: Restraining Circulating Tumor Cells from Initiating Metastatic Cascade
Adhesion of circulating tumor cells (CTCs) to vascular endothelial bed becomes a crucial starting point in metastatic cascade. We hypothesized that nitric oxide (NO) may prevent cancer metastasis from happenin...
