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Open AccessThe causal relationship between blood cell indices and 28-day mortality in sepsis: a retrospective study and bidirectional Mendelian randomization analysis
Despite emerging evidence linking blood cell indices (BCIs) to sepsis mortality, the inconsistency of observational studies obscures the clarity of these associations. This study aims to clarify the causal inf...
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Article
Open AccessIncidence and Outcomes of Brucella Endocarditis in a High-Prevalence Area: A Single-Center Study
To analyze the clinical characteristics of Brucella endocarditis (BE) and observe the factors related to death to provide guidance for clinical treatment.
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Open AccessIdentification of common stria vascularis cellular alteration in sensorineural hearing loss based on ScRNA-seq
The stria vascularis (SV), located in the lateral wall of the cochlea, maintains cochlear fluid homeostasis and mechanoelectrical transduction (MET) activity required for sound wave conduction. The pathogenesi...
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Open AccessChina nationwide landscape of 16 types inherited metabolic disorders: a retrospective analysis on 372,255 clinical cases
Inherited metabolic disorders (IMDs) usually occurs at young age and hence it severely threatening the health and life of young people. While so far there lacks a comprehensive study which can reveals China’s ...
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Article
Open AccessReliability and Agreement of an Integrated Platform for Intelligent Visual Function Measurement
Phoropters are widely accepted for clinical use in refraction examination and visual function assessment. This study assessed the reliability of the new Inspection Platform of Visual Function (IPVF) in compari...
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Article
Open AccessPharmaceutical targeting Th2-mediated immunity enhances immunotherapy response in breast cancer
Breast cancer is a complex disease with a highly immunosuppressive tumor microenvironment, and has limited clinical response to immune checkpoint blockade (ICB) therapy. T-helper 2 (Th2) cells, an important co...
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Article
Open AccessDistributed implantation of a flexible microelectrode array for neural recording
Flexible multichannel electrode arrays (fMEAs) with multiple filaments can be flexibly implanted in various patterns. It is necessary to develop a method for implanting the fMEA in different locations and at v...
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Article
Open AccessCurcumin sensitizes response to cytarabine in acute myeloid leukemia by regulating intestinal microbiota
To address whether Curcumin has synergistic effect with cytarabine (Ara-C) in treating acute myeloid leukemia (AML).
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Retraction Note: Image simulation of coastal climate and badminton sports based on SAR remote sensing images
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Open AccessStructural basis for ligand recognition of the neuropeptide Y Y2 receptor
The human neuropeptide Y (NPY) Y2 receptor (Y2R) plays essential roles in food intake, bone formation and mood regulation, and has been considered an important drug target for obesity and anxiety. However, develo...
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Article
Open AccessVariation of rhizosphere microbial community in continuous mono-maize seed production
Soil microbe is crucial to a healthy soil, therefore its diversities and abundances under different conditions are still need fully understand.The aims of the study were to characterize the community structure...
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Open AccessDisrupted architecture and fast evolution of the mitochondrial genome of Argeia pugettensis (Isopoda): implications for speciation and fitness
Argeia pugettensis is an isopod species that parasitizes other crustaceans. Its huge native geographic range spans the Pacific from China to California, but molecular data are available only for a handful of spec...
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Open AccessOrganosulfide-plasticized solid-electrolyte interphase layer enables stable lithium metal anodes for long-cycle lithium-sulfur batteries
Lithium metal is a promising anode candidate for the next-generation rechargeable battery due to its highest specific capacity (3860 mA h g−1) and lowest potential, but low Coulombic efficiency and formation of l...
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Open AccessMicroRNA-181c inhibits cigarette smoke–induced chronic obstructive pulmonary disease by regulating CCN1 expression
Chronic obstructive pulmonary disease (COPD) is an obstinate pulmonary disease, causing irreversible alveoli collapse and increasing the risk for cardiovascular disease. Accumulating evidence has shown that th...
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Open AccessDiscovery and ramifications of incidental Magnéli phase generation and release from industrial coal-burning
Coal, as one of the most economic and abundant energy sources, remains the leading fuel for producing electricity worldwide. Yet, burning coal produces more global warming CO2 relative to all other fossil fuels, ...