41 Result(s)
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**ufeng Liu
Life Sciences
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Article
Rapid and specific detection of Chinook salmon bafinivirus (CSBV) in flatfish using loop-mediated isothermal amplification (LAMP)
It is now understood that the flatfish farming industry faces significant threats from Chinook salmon bafinivirus (CSBV) induced hemorrhagic disease. Develo** a prompt and efficient diagnostic method is cruc...
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Open AccessApurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer
APE1 is an essential gene involved in DNA damage repair, the redox regulation of transcriptional factors (TFs) and RNA processing. APE1 overexpression is common in cancers and correlates with poor patient surv...
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Heterologous expression and fibrillary characterization of the microtubule-binding domain of tau associated with tauopathies
Neurofibrillary tangles (NFTs) are one of the most common pathological characteristics of Alzheimer’s disease. The NFTs are mainly composed of hyperphosphorylated microtubule-associated tau. Thus, recombinant ...
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GALNT2, an O-glycosylating enzyme, is a critical regulator of radioresistance of non-small cell lung cancer: evidence from an integrated multi-omics analysis
Radioresistance is the primary reason for radiotherapy failure in non-small cell lung cancer (NSCLC) patients. Glycosylation-related alterations are critically involved in tumor radioresistance. However, the r...
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PKCι induces differential phosphorylation of STAT3 to modify STAT3-related signaling pathways in pancreatic cancer cells
An increasing number of studies have documented atypical protein kinase C isoform ι (PKCι) as an oncoprotein playing multifaceted roles in pancreatic carcinogenesis, including sustaining the transformed growth...
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Microorganisms regulate soil phosphorus fractions in response to low nocturnal temperature by altering the abundance and composition of the pqqC gene rather than that of the phoD gene
Low nocturnal temperature (LNT) is a primary limitation in the greenhouse cultivation of vegetables during winter and spring, because it limits the availability of soil phosphorus (P), causing P-deficient symp...
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Open AccessAcaricidal and repellent activities of ethanol extracts of nine chinese medicinal herbs against Rhipicephalus microplus (Acari: Ixodidae)
Rhipicephalus microplus is a major threat to the cattle industry worldwide. The intensive use of acaricides and repellents has resulted in drug resistance. Hence, effective and eco-friendly pest control alternati...
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BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets
BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We gathered a diverse set of image volumes across several species t...
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LBCE-XGB: A XGBoost Model for Predicting Linear B-Cell Epitopes Based on BERT Embeddings
Accurately detecting linear B-cell epitopes (BCEs) makes great sense in vaccine design, immunodiagnostic test, antibody production, disease prevention and treatment. Wet-lab experiments for determining linear ...
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Article
Clock genes are expressed in cementum and regulate the proliferation and mineralization of cementoblasts
Circadian clock genes are present in the ameloblasts, odontoblasts, and dental pulp cells. The cementum plays a vital role in connecting the roots of teeth to the alveolar bone by anchoring the periodontal lig...
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Open Access4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer
Nutrient-limiting conditions are common during cancer development. The coordination of cellular glucose levels and cell survival is a fundamental question in cell biology and has not been completely understood...
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Open AccessInsights into divalent cation regulation and G13-coupling of orphan receptor GPR35
Endogenous ions play important roles in the function and pharmacology of G protein-coupled receptors (GPCRs) with limited atomic evidence. In addition, compared with G protein subtypes Gs, Gi/o, and Gq/11, insuff...
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Molecular characterization and functional analysis of a pathogenesis-related β-1,3-glucanase gene in spruce (Picea asperata)
β-1,3-glucanase, a member of the plant PR-2 family of pathogenesis-related (PR) proteins and Glycoside Hydrolase Family 17 (GH17), plays an important role in plant defense mechanisms against pathogens. In this...
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Article
Open AccessGNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer
Glycogen-Interacting Protein 1 (GNIP1), an E3 ligase, is a member of the tripartite motif (TRIM) family proteins. Current studies on GNIP1 mainly focus on glycogen metabolism. However, the function and molecul...
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Article
Recombinant jurkat cells (HMGN2-T cells) secrete cytokines and inhibit the growth of tumor cells
High Mobility Group Chromosomal Protein N2 (HMGN2) can recognize tumor cells and enhance the anti-tumor effect of immune cells. This study aimed to establish a lentiviral vector of recombinant HMGN2 gene, esta...
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Open AccessSingle-cell RNA sequencing reveals the potential mechanism of heterogeneity of immunomodulatory properties of foreskin and umbilical cord mesenchymal stromal cells
Mesenchymal stromal cells (MSCs) are heterogeneous populations. Heterogeneity exists within the same tissue and between different tissues. Some studies have found enormous heterogeneity in immunomodulatory fun...
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Open AccessCytochrome B5 type A alleviates HCC metastasis via regulating STOML2 related autophagy and promoting sensitivity to ruxolitinib
The incidence of hepatocellular carcinoma (HCC) is increasing in the world. However, its role and underlying molecular mechanism in HCC progression remain unclear. We found that CYB5A plays a key role in HCC m...
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Article
Application of galactinol to tomato enhances tolerance to cold and heat stresses
Galactinol, a galactosyl donor, is the key substrate in raffinose family oligosaccharide (RFO) biosynthesis pathways. Many studies proved that galactinol also regulates some defense-related genes to be transcr...
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Open AccessIdentification and validation of serum autoantibodies in children with B-cell acute lymphoblastic leukemia by serological proteome analysis
B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy of childhood. Even though significant progresses have been made in the treatment of B-ALL, some pediatric B-ALL have still poor prognos...
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Molecular Identification and Antifungal Activity of a Defensin (PaDef) from Spruce
Defensins, as part of the PR protein family, not only have antimicrobial activity in vitro, but also play an important role in plant disease resistance. To explore the molecular function of defensin in spruce,...
