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Article
Experimental study on fracture infiltration and slurry permeation reduction based on 3D printed visualization models
The seepage and slurry filling permeability reduction laws in rock mass fracture network are investigated through the construction of a two-dimensional fracture network model, which is based on real rock sampl...
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Article
Open AccessAcetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors
Despite the importance of spliceosome core components in cellular processes, their roles in cancer development, including hepatocellular carcinoma (HCC), remain poorly understood. In this study, we uncover a c...
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Article
Novel Iminocoumarin-substituted Tetraphenylethylene-based Near-infrared Fluorescent Probe for Ratiometric Detection of F− and H2S
An iminocoumarin and tetraphenylethylene compound that exhibits aggregation-induced emission (AIE) and a significant Stokes shift (Δλ = 135 nm) in THF was created via the Knoevenagel condensation method. TPICBT c...
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Article
Open AccessWogonin upregulates SOCS3 to alleviate the injury in Diabetic Nephropathy by inhibiting TLR4-mediated JAK/STAT/AIM2 signaling pathway
Diabetic nephropathy (DN) is a life-threatening renal disease and needs urgent therapies. Wogonin is renoprotective in DN. This study aimed to explore the mechanism of how wogonin regulated high glucose (HG)-i...
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Article
Rapid and specific detection of Chinook salmon bafinivirus (CSBV) in flatfish using loop-mediated isothermal amplification (LAMP)
It is now understood that the flatfish farming industry faces significant threats from Chinook salmon bafinivirus (CSBV) induced hemorrhagic disease. Develo** a prompt and efficient diagnostic method is cruc...
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Article
Nanozymes for nanohealthcare
Nanozymes, nanomaterial-based artificial enzymes, exhibit potential for emulating the catalytic functions inherent in enzymes. Nanozymes have advantages such as low cost, facile synthesis, high stability and a...
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Article
Open AccessDual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial
Clinical outcomes of catheter ablation for atrial fibrillation (AF) are suboptimal due, in part, to challenges in achieving durable lesions. Although focal point-by-point ablation allows for the creation of an...
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Article
Open AccessFlash heating process for efficient meat preservation
Maintaining food safety and quality is critical for public health and food security. Conventional food preservation methods, such as pasteurization and dehydration, often change the overall organoleptic qualit...
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Article
The Anchoring effect for two types of vertically foliated slate with different layer thicknesses
Deep-buried steep thin-layered surrounding rock tunnels often face problems of cracking along the layers. Applying bolt supports is a relatively effective method of crack suppression. However, the anchoring ef...
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Article
Open AccessControlled condensation by liquid contact-induced adaptations of molecular conformations in self-assembled monolayers
Surface condensation control strategies are crucial but commonly require relatively tedious, time-consuming, and expensive techniques for surface-chemical and topographical engineering. Here we report a strate...
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Article
Open AccessA previously healthy 3-year-old female with hypertension, proteinuria, and hypercalciuria
A 3-year-old female patient with no significant medical history presented to her pediatrician with foamy urine. Initial testing revealed moderate proteinuria on qualitative testing, although she was incidental...
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Article
Open AccessScience teacher identity research: a sco** literature review
Science teacher identity significantly influences teacher professional development, practices, and attitudes, which in turn impacts student learning outcomes. With an increased number of studies on science tea...
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Article
The influence of representational gravity on spatial orientation: an eye movement study
Spatial orientation is a fundamental subject in aviation psychology. The influence of representational gravity can lead to systematic errors during uniform linear motion. However, it remains unclear whether re...
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Article
Open AccessTemporal network of experience sampling methodology identifies sleep disturbance as a central symptom in generalized anxiety disorder
A temporal network of generalized anxiety disorder (GAD) symptoms could provide valuable understanding of the occurrence and maintenance of GAD. We aim to obtain an exploratory conceptualization of temporal GA...
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Article
Open AccessBRAF/MEK-targeted therapy in BRAF ex15 p.T599dup mutation-driven NSCLC: a case report
BRAF mutations are found in 1–5% of non-small-cell lung cancer (NSCLC), with V600 and non-V600 accounting for approximately 50% each. It has been confirmed that targeted therapy with dabrafenib + trametinib is...
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Article
Open AccessOralExplorer: a web server for exploring the mechanisms of oral inflammatory diseases
Oral inflammatory diseases are localized infectious diseases primarily caused by oral pathogens with the potential for serious systemic complications. However, publicly available datasets for these diseases ar...
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Article
Open AccessApurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer
APE1 is an essential gene involved in DNA damage repair, the redox regulation of transcriptional factors (TFs) and RNA processing. APE1 overexpression is common in cancers and correlates with poor patient surv...
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Article
Open AccessProteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma
Soft tissue sarcoma is a broad family of mesenchymal malignancies exhibiting remarkable histological diversity. We portray the proteomic landscape of 272 soft tissue sarcomas representing 12 major subtypes. Hi...
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Article
Open AccessA network analysis bridging the gap between the big five personality traits and burnout among medical staff
Burnout is a common issue among medical professionals, and one of the well-studied predisposing factors is the Big Five personality traits. However, no studies have explored the relationships between these tra...
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Article
Heterologous expression and fibrillary characterization of the microtubule-binding domain of tau associated with tauopathies
Neurofibrillary tangles (NFTs) are one of the most common pathological characteristics of Alzheimer’s disease. The NFTs are mainly composed of hyperphosphorylated microtubule-associated tau. Thus, recombinant ...
