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Article
Decoding the biochemical dialogue: metabolomic insights into soybean defense strategies against diverse pathogens
Soybean, a crucial global leguminous crop, confronts persistent threats from diverse pathogens, exerting a profound impact on global yields. While genetic dimensions of soybean-pathogen interactions have garne...
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Article
Open AccessDevelo** an entrustable professional activity for providing health education and consultation in occupational therapy and examining its validity
Entrustable Professional Activities (EPA)-based assessment is easily and intuitively used in evaluating the learning outcomes of competency-based medical education (CBME). This study aimed to develop an EPA fo...
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Article
Open AccessAnti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
Tau is aberrantly acetylated in various neurodegenerative conditions, including Alzheimer’s disease, frontotemporal lobar degeneration (FTLD), and traumatic brain injury (TBI). Previously, we reported that red...
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Article
Application of optimized random forest regressors in predicting the maximum principal stress of aseismic tunnel lining
Using flexible dam** technology to improve tunnel lining structure is an emerging method to resist earthquake disasters, and several methods have been explored to predict mechanical response of tunnel lining...
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Article
Open AccessTopoisomerase I is an evolutionarily conserved key regulator for satellite DNA transcription
RNA Polymerase (RNAP) II transcription on non-coding repetitive satellite DNAs plays an important role in chromosome segregation, but a little is known about the regulation of satellite transcription. We here ...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Open AccessDAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer
Metabolic reprogramming has become increasingly important in tumor biology research. The glucose metabolic pathway is a major energy source and is often dysregulated in breast cancer. DAB2IP is widely reported...
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Article
Di- and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair
Histone H3 Lys36 (H3K36) methylation and its associated modifiers are crucial for DNA double-strand break (DSB) repair, but the mechanism governing whether and how different H3K36 methylation forms impact repa...
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Article
Open AccessA qualitative study on inner experience of self-management behavior among elderly patients with type 2 diabetes in rural areas
As a chronic metabolic disease, diabetes poses a serious threat to human health and has become a major public health problem in China and worldwide. In 2020, 30% of Chinese people (aged ≥ 60 years) reported ha...
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Open AccessCardiovascular outcomes associated with SGLT2 inhibitor therapy in patients with type 2 diabetes mellitus and cancer: a systematic review and meta-analysis
Cancer patients with diabetes are at increased risk for cardiovascular diseases due to common risk factors and well-documented drug-associated cardiotoxicity. Sodium-glucose cotransporter-2 (SGLT2) inhibitors ...
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Article
Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention
Rheumatoid arthritis (RA) is a worldwide public health problem. Interventions to delay or prevent the onset of RA have attracted much attention in recent years, and researchers are now exploring various preven...
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Article
Open AccessSyndecan-4 is required for early-stage repair responses during zebrafish heart regeneration
The healing process after a myocardial infarction (MI) in humans involves complex events that replace damaged tissue with a fibrotic scar. The affected cardiac tissue may lose its function permanently. In cont...
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Article
Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation
To identify the core targets of Rheum palmatum L. and Salvia miltiorrhiza Bge., (Dahuang-Danshen, DH-DS) and the mechanism underlying its therapeutic efficacy in acute pancreatitis (AP) using a network pharmacolo...
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Article
Open AccessHyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine
Abnormal phosphorylation of the microtubule-binding protein tau in the brain is a key pathological marker for Alzheimer’s disease and additional neurodegenerative tauopathies. However, how hyperphosphorylated ...
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Article
Open AccessUSP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy
Drug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue is important and urgent. In this study, we found that targeting USP24 by the specific USP24 inhi...
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Article
Open AccessRibosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis
Although previous studies have examined the signaling pathway involved in melanogenesis through which ultraviolet (UV) or α-melanocyte-stimulating hormones (α-MSH) stimuli act as key inducers to produce melani...
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Article
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
Proteolysis targeting chimeras (PROTACs) have emerged as revolutionary anticancer therapeutics that degrade disease-causing proteins. However, the anticancer performance of PROTACs is often impaired by their i...
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Article
The association between prealbumin concentration at admission and mortality in elderly patients with hip fractures: a cohort study
Malnutrition is associated with complications and mortality in patients of hip fracture. Prealbumin may be more suitable than albumin to accurately predict the prognosis of hip fracture in elderly patients. We...
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Article
Element analysis of limestone based on inelastic neutron scattering system
In this work, an inelastic neutron scattering system was developed for element analysis in limestone with a D–T neutron generator and a 3*3 inch LaBr3 detector. Six sets of simulated limestone samples were prepar...
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Article
Development of comprehension monitoring skill in Chinese children: evidence from eye movement and probe interviews
As an important construct in the cognitive process, comprehension monitoring has received much scholarly attention. Researchers have recognized comprehension monitoring as an ability closely linked with childr...
