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Article
Open AccessThe IMPDH cytoophidium couples metabolism and fetal development in mice
The cytoophidium is an evolutionarily conserved subcellular structure formed by filamentous polymers of metabolic enzymes. In vertebrates, inosine monophosphate dehydrogenase (IMPDH), which catalyses the rate-...
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Article
Open AccessDiversity and potential host-interactions of viruses inhabiting deep-sea seamount sediments
Seamounts are globally distributed across the oceans and form one of the major oceanic biomes. Here, we utilized combined analyses of bulk metagenome and virome to study viral communities in seamount sediments...
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Article
Open AccessCircular olefin copolymers made de novo from ethylene and α-olefins
Ethylene/α-olefin copolymers are produced in huge scale and widely used, but their after-use disposal has caused plastic pollution problems. Their chemical inertness made chemical re/upcycling difficult. Ideal...
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Article
Open AccessMulti-ancestry genome-wide association study of major depression aids locus discovery, fine map**, gene prioritization and causal inference
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD ...
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Article
Metabonomic Investigation of Penicillium expansum Infection of Apples and Salicylic Acid-Mediated Disease Resistance
Blue mold caused by Penicillium expansum infection results in severe postharvest deterioration of apples. Salicylic acid (SA) is an effective elicitor of fruit resistance. However, the metabolic mechanism of P. e...
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Article
Open AccessLow-to-Moderate Arsenic Exposure and Urothelial Tract Cancers with a Long Latent Period of Follow-Up in an Arseniasis Area
Arsenic exposure can cause adverse health effects. The effects of long-term low-to-moderate exposure and methylations remain unclear.
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Article
Open AccessAPE1 promotes non-homologous end joining by initiating DNA double-strand break formation and decreasing ubiquitination of artemis following oxidative genotoxic stress
Apurinic/apyrimidinic endonuclease 1 (APE1) imparts radio-resistance by repairing isolated lesions via the base excision repair (BER) pathway, but whether and how it is involved in the formation and/or repair ...
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Article
Open AccessVerifying the accuracy of self-reported smoking behavior in female volunteer soldiers
Smoking rates in the military are evaluated through questionnaire surveying. Because the accurate identification of smokers facilitates the provision of smoking cessation services, this study conducted urine c...
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Article
Open AccessIron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity
Endometriosis (EMs) occurs in approximately 50% of women with infertility. The main causes of EMs-related infertility are follicle dysplasia and reduced oocyte quality. Iron overload occurs in ovarian follicul...
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Article
Open AccessSex differences following percutaneous coronary intervention or coronary artery bypass surgery for acute myocardial infarction
Women have been underrepresented in the literature; the effects of female sex on outcomes in patients with acute myocardial infarction (AMI) remain unclear.
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Article
Open AccessALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis
Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m1A RNA modification plays key roles in RNA metabolism and gene e...
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Article
Open AccessMore than causing (epi)genomic instability: emerging physiological implications of transposable element modulation
Transposable elements (TEs) initially attracted attention because they comprise a major portion of the genomic sequences in plants and animals. TEs may jump around the genome and disrupt both coding genes as w...
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Article
Open AccessTranscriptomics identifies key defense mechanisms in rice resistant to both leaf-feeding and phloem feeding herbivores
Outbreaks of insect pests in paddy fields cause heavy losses in global rice yield annually, a threat projected to be aggravated by ongoing climate warming. Although significant progress has been made in the sc...
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Article
Open AccessThe impact of urine microbiota in patients with lower urinary tract symptoms
Inflammation and infection are causative factors of benign prostatic hyperplasia (BPH). Urine is not sterile, and urine microbiota identified by DNA sequencing can play an important role in the development of ...
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Article
Open AccessSurvival and diagnostic age of 175 Taiwanese patients with mucopolysaccharidoses (1985–2019)
Mucopolysaccharidoses (MPSs) are a group of inherited metabolic diseases, which are characterized by the accumulation of glycosaminoglycans, and eventually lead to the progressive damage of various tissues and...
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Article
CT-based radiomics for preoperative prediction of early recurrent hepatocellular carcinoma: technical reproducibility of acquisition and scanners
To test the technical reproducibility of acquisition and scanners of CT image-based radiomics model for early recurrent hepatocellular carcinoma (HCC).
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Article
Map** and characterization of major QTL for spike traits in common wheat
The spike traits of wheat can directly affect yield. F2 and F2:3 lines derived from the cross of the multi-spikelet female 10-A and the uni-spikelet male BE89 were used to detect QTLs for spike length (SL), total...
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Article
The presence of microvascular invasion guides treatment strategy in recurrent HBV-related HCC
We used the status of microvascular invasion (MVI) at primary resection to help treatment selection for hepatitis B virus–positive (HBV+) recurrent hepatocellular carcinoma (rHCC) patients in Barcelona Clinic ...
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Article
Open AccessThree-Dimensional CuO/TiO2 Hybrid Nanorod Arrays Prepared by Electrodeposition in AAO Membranes as an Excellent Fenton-Like Photocatalyst for Dye Degradation
Three-dimensional (3D) CuO/TiO2 hybrid heterostructure nanorod arrays (NRs) with noble-metal-free composition, fabricated by template-assisted low-cost processes, were used as the photo-Fenton-like catalyst for d...
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Article
Open AccessTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrow...
