7,204 Result(s)

Article

REDUCED HEART LIPID PEROXIDATION IN DILATED CARDIOMYOPATHY

Nitrofurantoin induced pulmonary fibroais may result from free radical(FR) production and subsequent lipid peroxidation(LPO). Furazolidone(FZ), a nitrofuran antibiotic, causes a dilated cardiomyopathy(CM) in t...

Daniela Lax, Shu-Lun Zhang, Ying Li, Lee Williams, James M Berry… in Pediatric Research (1987)

Article

ACETALDEHYDE INCREASES FREE IRON IN THE HEART: POSSIBLE MECHANISM IN ALCOHOL CAHDIOMYOPATHY

Chronic alcohol(ETOH) exposure in man and turkeys (TK) leads to structural and functional changes in the heart; similar cardiac pathology has been found in some infants with the fetal alcohol syndrome. The mec...

Shu-Lun Zhang, Daniela Lax, Ying Li, Lee Williams, Nancy A Staley… in Pediatric Research (1987)

Article

Laboratory and clinical diagnosis of human cytomegalovirus infection after transplantation

Urine and blood specimens from 32 recipients of allograft organ transplant were investigated for human cytomegalovirus (HCMV) by conventional cell culture, indirect immunofluo.rescent assay subsequent to the r...

Duan Yan-**, Chen **u-zhu, Zhang **n, Liu Dun-gui… in Journal of Tongji Medical University (1990)

Article

Isoforms of Mammalian Cytochrome c Oxidase:Correlation with Human Cytochrome c Oxidase Deficiency

ABSTRACT: We have reviewed the structure, function, and biogenesis of mammalian cytochrome c oxidase, examined the tissue-specific expression of isoforms of cytochrome c oxidase subunits in different mammals, ...

Nancy G Keenaway, Rooque D Carrero-Valenzuela, Gary Ewart… in Pediatric Research (1990)

Article

Genotypic Confirmation from the Original Dried Blood Specimens in a Neonatal Hemoglobinopathy Screening Program

ABSTRACT: Dried blood spots are used for newborn screening because of ease of sample collection, handling, and shipment. DNA is stable and accessible in the filter paper matrix. Genotypic confirmation using in...

Maria Descartes, Ying Huang, Yao Hua Zhang, Linda L McCabe… in Pediatric Research (1992)

Article

HOMOZYGOUS DELETION OF AMINO ACIDS 487–489 IN P450c17 CAUSES SEVERE 17α-HYDROXYLASE (17-OH) DEFICIENCY

17-OH and 17,20 lyase activities are mediated by cytochrome P450cl7. 17-OH deficiency is rare and only a few cases have been investigated at a molecular genetic level. A 14 y. o. female from rural Thailand was...

Carlos E Fardella, Linhua Zhang, Pat Mahachoklertwattana, Dong Lin… in Pediatric Research (1993)

Article

Studies of Immunomodulating Actions of RNA/Nucleotides. RNA/Nucleotides Enhance In Vitro Immunoglobulin Production by Human Peripheral Blood Mononuclear Cells in Response to T-Dependent Stimuli

ABSTRACT: We have shown previously that yeast RNA preparations enhance in vitro antibody and Ig production to T-dependent antigens in normal B6 mice. In this study, Ig production by human peripheral blood mononuc...

Harumi Jyonouchi, Lei Zhang, Yoshifumi Tomita in Pediatric Research (1993)

Article

Effects of Gestational Exposure to Monoamine Oxidase Inhibitors in Rats: Preliminary Behavioral and Neurochemical Studies

Monoamine neurotransmitters are important in the development of the immature mammalian brain, prior to assuming their role as neurotransmitters. The endogenous levels of these transmitters are highly regulated...

Patricia M. Whitaker-Azmitia Ph.D., **ni Zhang Ph.D.… in Neuropsychopharmacology (1994)

Article

Dopamine Directly Activates Human 5-HT_1C Receptors Expressed in Xenopus Oocytes

The activation of human 5-HT_1C receptors by dopamine was studied in Xenopus oocytes voltage clamped at −70 mV. 5-HT_1C receptors were expressed by microinjection of human cRNA transcripts (Biochem. Biophys. Res. C...

M Oz, L Zhang, DH Yu, FF Weight in Neuropsychopharmacology (1994)

Article

Dopamine Directly Activates 5-HT₃ Receptors Expressed in Xenopus Oocytes

The activation of 5-HT₃ receptors by dopamine was studied in Xenopus oocytes voltage clamped at −70 mV. 5-HT₃ receptors were expressed by the microinjection of cRNA transcripts from the cloned 5-HT₃ receptor (Sci...

M Oz, L Zhang, FF Weight in Neuropsychopharmacology (1994)

Article

NMDA Receptors Mediate Diffuse Homolateral Cerebrocortical Changes in Gene Expression Following a Minimal Cortical Lesion

A small surgical lesion of the parietal cortex induces an increase in gene expression varying from 172 to 980% in the entire homolateral cerebral cortex, as detected by quantitative in situ hybridization histo...

Laurence Van Brée, Fan Zhang, Pierre Mailleux… in Neuropsychopharmacology (1994)

Article

Effect of cocaine on 5-HT₃ Receptor-Mediated Ion Current in Xenopus Oocytes

The 5-HT₃ receptor, a ligand-gated ion channel, has been proposed to be involved in brain mechanisms associated with drug abuse (Costall et al., Pharmac. Ther. 47: 181, 1990). In the present study, the effect of ...

P Fan, M Oz, L Zhang, FF Weight in Neuropsychopharmacology (1994)

Article

Beta Adrenoceptor Blockade Mimics Effects of Stress on Motor Activity in Mice

Reduced central noradrenergic function has been implicated as a factor in reduced behavioral activity after stress. The present studies examined the role of reduced beta adrenergic neurotransmission in mediati...

Eric A Stone Ph.d, Sanil J Manavalan MD, Yi Zhang MD… in Neuropsychopharmacology (1995)

Article

Frequency and Cytokine Phenotype of Blood T Cells from Premature Infants Responding to Staphylococcal Enterotoxin B

ABSTRACT: The responder cell frequency (RCF) of premature (<1900 g birth weight) infants' blood lymphocytes, which proliferate in cultures stimulated by staphylococcal enterotoxin B, falls from 1:3400 to about...

Anthony R Hayward, Mary Cosyns, Yingjian Zhang in Pediatric Research (1995)

Article

Absence of Molecular Defect in the Type II 3β-Hydroxysteroid Dehydrogenase (3β-HSD) Gene in Premature Pubarche Children and Hirsute Female Patients with Moderately Decreased Adrenal 3β-HSD Activity

ABSTRACT: To date the molecular basis and hormonal criteria for inherited mild late-onset 3β-hydroxysteroid dehydrogenase (3β-HSD) deficiency congenital adrenal hyperplasia (CAH) have not been defined. We have...

Ying T Chang, L I Zhang, Hala S Alkaddour, J Ian Mason, Kemming Lin… in Pediatric Research (1995)

Article

Perinatal Nitric Oxide Synthase Inhibition Retards Neonatal Growth by Inducing Hypertrophic Pyloric Stenosis in Rats

ABSTRACT: Administration of the nitric oxide synthase (NOS) inhibitor, N^G-nitro-L-arginine methyl ester (L-NAME) during pregnancy has been shown to compromise fetal growth. This study was designed to determine wh...

Cynthia A Voelker, Mark J S Miller, **ao-**g Zhang… in Pediatric Research (1995)

Article

The role of cerebro-ponto-cerebellar pathways in the control of vergence eye movements

Single-unit recording and anatomical techniques have been used in Rhesus monkeys to investigate the central pathways involved in the neural control of vergence and ocular accommodation. Anatomical studies have...

Paul D R Gamlin, Kyunghee Yoon, Hongyu Zhang in Eye (1996)

Article

cDNA AND PROMOTER GENE STRUCTURE OF RABBIT WILD TYPE (Wt) CYTOCHROME P450 CHOLESTEROL SIDE-CHAIN-CLEAVAGE (SCC) ENZYME. 590

**aojiang Yang, Keming Lin, Li Zhang, J. Ian Mason, **ming Yang… in Pediatric Research (1996)

Article

STUDIES OF 3β-HYDROXYSTEROID DEHYDROGENASE (3β-HSD) GENES IN INFANTS AND CHILDREN MANIFESTING PREMATURE PUBARCHE (PP) AND INCREASED ACTH STIMULATED Δ5 STEROID LEVELS. † 573

Hala Sakkal-Alkaddour, Li Zhang, **aojiang Yang, Ying T Chang… in Pediatric Research (1996)

Article

BACTERIAL SPECIES IDENTIFICATION AFTER AMPLIFICATION WITH A UNIVERSAL PRIMER PAIR. † 1059

Kevin M McCabe, Yao-Hua Zhang, Bing-Ling Huang, Su-Ting Li… in Pediatric Research (1996)